国际医药卫生导报2013，Vol.19Issue(23)：3534-3537,4.DOI:10.3760/cma.j.issn.1007-1245.2013.23.002
褪黑素联合化疗对晚期食管癌患者的影响研究
Melatonin in combination with chemotherapy for patients with advanced esophageal cancer
摘要
Abstract
Objective To provide some evidences for treating advanced esophageal cancer exploring the effect of melatonin in combination with chemotherapy on patients with advanced esophageal cancer.Methods 40 patients with advanced esophageal cancer undergoing initial treatment were selected from our hospital from June,2011 to May,2013 as research objects (observation group).Another 40 patients with advanced esophageal cancer undergoing initial treatment were enrolled into the control group.The observation group was treated with melatonin and chemotherapy,while the control group was treated with only chemotherapy.The clinical efficacies,Karnofsky behavior scores,and the indicators of T lymphocyte subsets in peripheral blood of both groups were evaluated.Results 10 cases (25.00％) got complete remission and 17 cases (42.50％) got partial remission in the observation group with a total effective rate of 67.50％.9 cases (22.50％) got complete remission and 17 cases (42.50％) got partial remission in the control group with a total effective rate of 65.00％.There was no statistical difference in total effective rate between the two groups (P ＞ 0.05).15 cases (37.50％) got better,21 cases (52.50％) were stable,and 4 cases (10.00％) deteriorated in Karnofsky behavior score in the observation group,which were better than that in the control group,with statistical differences (P ＜ 0.05).CD3+ and CD4+ levels were significantly higher in the observation group than in the control group,with statistical differences (P ＜ 0.05).There was no statistical difference in CD8+level between the two groups (P＞0.05).CD4+/CD8+ ratio was significantly higher in the observation group than in the control group,with a statistical difference (P ＜ 0.05).Conclusions Melatonin in combination with chemotherapy has little influence on the clinical curative effect of patients with advanced esophageal cancer,but can improve the patients' immunity and reduce adverse reactions,enhance the efficacy in tumor auxiliary treatment,and reduce toxicity effect.关键词
褪黑素/化疗/晚期食管癌Key words
Melatonin/ Chemotherapy/ Advanced esophageal cancer引用本文复制引用
张盛奇,林丽芳,郑泓斌,方玫玫..褪黑素联合化疗对晚期食管癌患者的影响研究[J].国际医药卫生导报,2013,19(23):3534-3537,4.基金项目
汕头市科技计划资助项目(汕府科[2011]46号) （汕府科[2011]46号）
