国际医药卫生导报2013，Vol.19Issue(24)：3776-3778,3.DOI:10.3760/cma.j.issn.1007-1245.2013.24.035
CYP2C19基因多态性和风险评分与经皮冠状动脉介入术后预后的关系
The relationship between CYP2C19 gene polymorphism and the risk score and prognosis after percutaneous coronary intervention
王涛 1陆东风 1曾昭华 1卜彤 1曾智1
作者信息
- 1. 510120 广州,广州医科大学附属第一医院
- 折叠
摘要
Abstract
Objective To investigate the relation between CYP2C19 polymorphisms and risk score and prognosis after percutaneous coronary intervention (PCI).Methods From March in 2012 to July in 2012 we randomly selected 40 patients who received PCI treatment and took their blood for the test of CYP2C 19 before admission.The CYP2C 19 genotypes were divided into three groups:extensive metabolisms,medium metabolisms and poor metabolisms.Results The PRI VASP ≥ 50％ of the patients in 6 cases,the PRI VASP ＜ 50％ of the patients in 34 cases,between the two groups of PRI VASP ratio of (55.97 ± 2.98) than (44.01-± 4.16),the difference had statistical significance (P ＜ 0.05).Through multiple regression analysis,this paper analyzes the factors which lead to the PCI postoperative adverse end point events concluded:aging,CYP2C19 poor metabolism,T2DM,LVEF,Renal insufficiency,the five factors for the high risk factors.Conclusion For patients with poor metabolism we can increase the dose of clopidogrel and combining Aspirin to prevent heart attacks.关键词
CYP2C19/风险评分/经皮冠状动脉术Key words
CYP2C19/ Risk score/ Percutaneous coronary intervention引用本文复制引用
王涛,陆东风,曾昭华,卜彤,曾智..CYP2C19基因多态性和风险评分与经皮冠状动脉介入术后预后的关系[J].国际医药卫生导报,2013,19(24):3776-3778,3.
