摘要
Abstract
Objective To explore the correlation between fibroblast growth factor 23(FGF23) and renal impairment in patients with chronic heart failure (CHF).Methods 289 patients with CHF were included in the present study.According to the glomerular filtration rate,289 patients were divided into three groups,including the normal renal function group,the mild renal dysfunction group and the moderate and severe renal dysfunction group.On admission,the serum FGF23,N-terminal pro-brain natriuretic peptide (NT-proBNP),creatinine (Cr) and blood urea nitrogen (BUN) were analyzed.The glomerular filtration rate (eGFR) was calculated.Left ejection fraction (EF) and left ventricular end-diastolic dimension were measured by ultrasonic cardiogram.Results The same trend of cardiac and renal function deterioration was observed in patients of the three groups.With the deterioration of renal function,the serum FGF23 was increased.Compared with the normal renal function group and the mild renal dysfunction group,FGF23 was significantly increased in patients of severe renal dysfunction group.The serum FGF23 was positively correlated with Cr,BUN and eGFR,and the correlation coefficents were 0.532,0.686 and 0.783 respectively,P ＜ 0.05.The serum FGF23 was positively correlated with NT-proBNP (r=0.652,P ＜ 0.05) and negatively correlated with EF (r=-0.521,P ＜ 0.05).Conclusion The degree of heart failure and heart failure with renal impairment were associated with the high level of serum FGF23.关键词
慢性心力衰竭/成纤维细胞生长因子23/肾脏损害Key words
Chtonic heart failure/ Fibroblast growth factor 23/ Renal impairment
