中国病理生理杂志2014，Vol.30Issue(3)：400-403,4.DOI:10.3969/j.issn.1000-4718.2014.03.003
穿心莲内酯对口腔癌生长的影响
Effect of andrographolide on oral squamous cell carcinogenesis
摘要
Abstract
AIM: To study the effect of andrographolide ( Andro) on oral squamous cell carcinogenesis . METHODS:Chemical-induced hamster buccal pouch cancer model was used .The tumor cell proliferation, apoptosis and microvessel density (MVD) were detected by immunohistochemical staining .RESULTS: Compared with control group, the tumor volume, MVD and tumor cell proliferation in Andro group were significantly decreased .The cell apoptotic cell number in Andro group was higher than that in control group .Caspase-3 was also activated in Andro group.CONCLU-SION:Andro inhibits tumor growth by suppressing proliferation , decreasing MVD and promoting apoptosis in the hamster buccal pouch.Furthermore, Andro promotes tumor cell apoptosis through caspase-3 pathway.关键词
穿心莲内酯/细胞凋亡/血管生成/口腔肿瘤Key words
Andrographolide/Apoptosis/Angiogenesis/Mouth neoplasms分类
医药卫生引用本文复制引用
亓翠玲,周鑫磊,叶杰,杨扬,章倩倩,李江超,兰天,何晓东,王丽京..穿心莲内酯对口腔癌生长的影响[J].中国病理生理杂志,2014,30(3):400-403,4.基金项目
国家自然科学基金资助项目(No.81270604) （No.81270604）
广东省自然科学基金重点项目(No.S2013020012863) （No.S2013020012863）
中央高校基本科研业务费专项资金资助项目(No.21612116) （No.21612116）
