中国病理生理杂志2014，Vol.30Issue(3)：563-566,4.DOI:10.3969/j.issn.1000-4718.2014.03.032
竞争性内源 RNA 与肿瘤发生
Competing endogenous RNAs and oncogenesis
蔺新秀 1杨蔓 1夏天 1郭俊明1
作者信息
- 1. 宁波大学医学院生物化学与分子生物学教研室，浙江省病理生理学技术研究重点实验室，浙江宁波315211
- 折叠
摘要
Abstract
Competing endogenous RNAs (ceRNAs) regulate other RNA transcripts by competing for shared microRNAs.They might be coding RNAs or non-coding RNAs including long non-coding RNAs, pseudogene transcripts, and circular RNAs.Recent discoveries reveal the important pathophysiological roles of ceRNAs in prostate cancer , colorec-tal cancer, melanoma, glioblastoma, liver cancer, breast cancer, etc.We discussed the molecular mechanisms of ceRNAs in cancers and their possible applications .In addition, several databases and algorithms , such as ceRDB, Linc2GO, star-Base, RNA22 and Hermes, have been developed for the convenience in ceRNA investigation .关键词
竞争性内源RNA/MicroRNA/肿瘤发生Key words
Competing endogenous RNAs/MicroRNA/Oncogenesis分类
医药卫生引用本文复制引用
蔺新秀,杨蔓,夏天,郭俊明..竞争性内源 RNA 与肿瘤发生[J].中国病理生理杂志,2014,30(3):563-566,4.
