癌变·畸变·突变Issue(1)：40-44,5.DOI:10.3969/j.issn.1004-616x.2014.01.009
AHNAK2蛋白在食管鳞癌中的表达及其临床意义
Expression and clinical relevance of AHNAK2 in esophageal squamous cell carcinoma
摘要
Abstract
OBJECTIVE:This study aimed to evaluate the expression and prognostic significance of AHNAK2 protein in esophageal squamous cell carcinoma (ESCC). METHODS:The alteration and clinical relevance of AHNAK2 protein levels were investigated in 129 ESCC cases by immunohistochemistry. RESULTS:The expression of AHNAK2 protein was up-regulated in some of ESCC tissues. Negative,weak,moderate and high expression of AHNAK2 were observed in 24.8% (32/129),28.7% (37/129),17.0% (22/129),and 29.5% (38/129) of tumors,respectively. Positive expression of AHNAK2 was significantly correlated with tumor differentiation (P=0.004). Kaplan-Meier survival curves showed that ESCC patients with negative expression of AHNAK2 had shorter overall survival time (P=0.027). Cox regression analysis indicated that AHNAK2 protein expression was an independent prognostic factor (P=0.018,HR=0.461,95%CI:0.243-0.877). CONCLUSION:AHNAK2 was overexpressed in ESCC tissues and correlated with tumor differentiation. AHNAK2 expression might contribute to the prognostic evaluation of patients with this disease.关键词
食管鳞状细胞癌/AHNAK2/免疫组化/组织微阵列/预后Key words
esophageal squamous cell carcinoma/AHNAK2/immunohistochemistry/tissue microarray/prognosis分类
医药卫生引用本文复制引用
刘荟娟,黄大可,贾雪梅,王明荣,商利,郝佳洁,蒋焱熠,石峰,王春丽,张钰,徐昕,蔡岩..AHNAK2蛋白在食管鳞癌中的表达及其临床意义[J].癌变·畸变·突变,2014,(1):40-44,5.基金项目
分子肿瘤学国家重点实验室开放基金(SKL-KF-2013-14-19)，863计划重大专项(2012AA02A503)，国家自然科学基金(81021061) （SKL-KF-2013-14-19）
