癌变·畸变·突变Issue(1)：45-48,4.DOI:10.3969/j.issn.1004-616x.2014.01.010
原癌基因Pim-3在胰腺癌组织中的表达及其与胰腺癌细胞增殖的相关性
Expression of Pim-3 in pancreatic carcinoma and its correlation with cell proliferation
陆平 1李云鹏 2高岩 3刘景波 1赵文杰 1刘言 1邢春艳1
作者信息
- 1. 齐齐哈尔医学院附属五院大庆龙南医院病理科，黑龙江 大庆 163453
- 2. 齐齐哈尔医学院附属五院大庆龙南医院妇产科，黑龙江 大庆163453
- 3. 齐齐哈尔医学院附属五院大庆龙南医院营养科，黑龙江 大庆 163453
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the expression of Pim-3 in pancreatic carcinoma and its correlation with cell proliferation. METHODS:The streptavidin-peroxidase complex technique was used to examine the expression of Pim-3 and PCNA proteins in 15 normal pancreatic tissue and 49 pancreatic carcinoma and the proliferative index (PI) was calculated. RESULTS:In normal pancreatic tissue Pim-3 was not detected,whereas in pancreatic carcinoma the positive expression ratio of Pim-3 was 73.47% (36/49).The positive rate of Pim-3 in pancreatic carcinoma was significantly higher than that in normal pancreatic tissue (P<0.01).The PI in normal pancreatic tissue and pancreatic duct adenocarcinoma was 6.25%±2.59% and 32.54%±14.69%,respectively,also with a significant difference (P<0.01).With the increase in the expression of Pim-3 protein,the cell proliferating activity increased in the tumor cells. The Pim-3 expression level was positively correlated with PI (r=0.726,P<0.01). CONCLUSION:Pim-3 was overexpresed in human pancreatic carcinoma,and it may play important roles in the carcinogenesis and progression of pancreatic carcinoma.关键词
胰腺癌/Pim-3/增殖细胞核抗原Key words
pancreatic carcinoma/Pim-3/proliferating cell nuclear antigen分类
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陆平,李云鹏,高岩,刘景波,赵文杰,刘言,邢春艳..原癌基因Pim-3在胰腺癌组织中的表达及其与胰腺癌细胞增殖的相关性[J].癌变·畸变·突变,2014,(1):45-48,4.
