癌变·畸变·突变Issue(1)：59-62,4.DOI:10.3969/j.issn.1004-616x.2014.01.014
冠心II号含药血清对心肌缺血再灌注样损伤的保护作用
Protection of Guanxin II Hao dr ug-containing ser um sample in myocardial ischemia-reperfusion injur y
摘要
Abstract
OBJECTIVE: To investigate the protective effects of Guanxin II Hao in myocardial ischemia-reperfusion injury. METHODS:Myocardial cells were cultured in vitro in a hypoxia/reoxygenation model,simulating myocardial ischemia reperfusion injury. The experiment was divided into 10%blank serum control group,10%Guanxin II Hao serum experimental group and 10%gathers the heart crisp serum the masculine control group. Myocardial cells with lactic acid dehydrogenase (LDH),creatine kinase (CK) release and malondialdehyde (MDA) content and superoxide dismutase (SOD) activity was evaluated. RESULTS:Guanxin II Hao group compared with the blank serum group, supernatant of cultured LDH release was significantly reduced(P<0.05);the amount of released CK was also decreased significantly(P<0.01). MDA content decreased significantly(P<0.05);whilst SOD activity was significantly enhanced (P<0.01). CONCLUSION:This Chinese medicine compound used for treating coronary heart disease showed protective effects on myocardial hypoxia/reoxygenation injury in vitro.关键词
冠心II号/含药血清/缺血再灌注样损伤Key words
Guanxin II Hao/medicated serum/ischemia reperfusion injury分类
医药卫生引用本文复制引用
马月香,高燕鲁,李晓,左广民..冠心II号含药血清对心肌缺血再灌注样损伤的保护作用[J].癌变·畸变·突变,2014,(1):59-62,4.基金项目
山东中医药大学资助课题(DXKT0608) （DXKT0608）
