安徽医科大学学报Issue(12)：1457-1460,1461,5.
羟基磷灰石/壳聚糖/聚乳酸复合材料对兔桡骨骨缺损的修复作用
Repair of radius bone defect with hydroxyapatite/chitosan/poly lactic composite
摘要
Abstract
Objective To study the effects of hydroxyapatite/ chitosan/ poly lactic composite in repair of bone de-fect. Methods Eighteen 3-month-old New Zealand white rabbits were randomly divided into experimental group and control group. Prepared 15 mm complete bone defect model at the bilateral radius, the experimental groups were implanted with HA/CS/PLLA composite and control groups were implanted nothing into the bone defect site. The bone defects of the animals were observed at the end of 4th week, 8th week and 12th week by anatomy, X-ray and histology methods, respectively. Results All the 18 rabbits entered the final analysis and no apparent reject reaction was found. At the end of the 12th week after operation the experimental group bone defects were repaired completely. However, the control group bone defects were not partially repaired. At the end of the 4th week, X-ray showed that osteotylus was seen in the defect area in the experimental group, and implants were mixed with the bone tissue of defects, and cortical continuity was better at the 12th week, the control group showed bone defect had not been partially repaired. Histological examination showed that lots of osteoblasts were seen in implants in the experimental group at the 4 th week, and began to connected to each other. At the 12th week, more woven bone-1 ike tissues were visible and trabecular-like structure was formed. Conclusion HA/ CS/ PLLA composite has good osteogenic potential and may be used to repair bone defect.关键词
羟基磷灰石/壳聚糖/聚乳酸/骨缺损/修复Key words
hydroxyapatite/chitosan/poly lactic/bone defect/repair分类
医药卫生引用本文复制引用
王云,董洲,张彩云,赵宇..羟基磷灰石/壳聚糖/聚乳酸复合材料对兔桡骨骨缺损的修复作用[J].安徽医科大学学报,2013,(12):1457-1460,1461,5.基金项目
国家自然科学基金(编号:81171829) （编号:81171829）
安徽省自然科学基金(编号:KJ2011ZD04) （编号:KJ2011ZD04）
