安徽医科大学学报Issue(12)：1527-1529,1530,4.
游泳运动和二甲双胍对肥胖大鼠chemerin蛋白表达水平的影响
Impact of treatment with swimming exercise and metformin on chemerin protein expression levels in different tissues of high-fat-diet-fed obesity rats
摘要
Abstract
Objective To observe the effects of swimming exercise, metformin and the combination of both inter-ventions on chemerin protein expression levels in epididymis adipose tissue ( EAT), subcutaneus adipose tissue ( SAT) and muscle tissue (MT) of obesity rats and to explore the relationship between chemerin and obesity-related metabolic disorders. Methods The 70 male conventional SD rats were divided into control diet group(n=10) and high fat group (n=60). After 16 weeks obesity model(n=40) was established and was randomly divided into four groups:high fat group(HF), swimming group(SWI), metformin group(MET), and the combination of swimming and metformin group(SAM) with 10 rats in each group. Chemerin protein expression levels in EAT, SAT and MT were determined by Western blot. Results ① After 22 weeks high fat diet induced obesity, chemerin protein ex-pression levels of obesity group in EAT, SAT and MT, especially that of EAT increased compared to NC group(P<0. 05).② After intervention, in EAT and SAT, chemerin expression levels of the group of SWI, MET and SAM significantly decreased, especially SAM. Chemerin expression levels of the group of MET, SWI and SAM in MT decreased with no statistical difference. Conclusion ① High fat diet could induce SD rats obesity and also in-crease the expression levels of chemerin protein in adipose tissue and muscle tissue. ②Swimming, metformin and the combination of both intervention could down-regulate the level of chemerin, especially in visceral adipose tis-sue.关键词
游泳运动/二甲双胍/chemerin/肥胖/代谢综合征Key words
swimming exercise/metformin/chemerin/obesity/metabolic syndrome分类
医药卫生引用本文复制引用
刘燕,戴武,王长江,胡红琳,代芳,夏莉..游泳运动和二甲双胍对肥胖大鼠chemerin蛋白表达水平的影响[J].安徽医科大学学报,2013,(12):1527-1529,1530,4.基金项目
安徽省教育厅资助项目(编号:KJ2009B047Z) （编号:KJ2009B047Z）
