安徽医科大学学报Issue(1)：59-62,63,5.
美洲大蠊及其不同提取物对急性免疫性肝损伤保护作用的比较
Compare the protection of Periplaneta American and its different extracts on acute immune liver injury
摘要
Abstract
Objective To investigate the effects of Periplaneta American and its different extracts on acute immuno-logical liver injury caused by concanavalin A( ConA) in mice. Methods The model of mice acute immunological liver injury was induced by ConA on day 10 after pretreatment with Periplaneta American and its different extracts. After 8 h, the mice were weighted, and blood were collected for determinate serum alanine aminotIansferas( ALT) and aspartate aminotransferas( AST) . Then the mice were killed, and the liver and spleen were weighted immediate-ly, and the liver and spleen index were calculated. The liver homogenates were prepared to test malondiadehyde (MDA),superoxidedismutase(SOD), glutathione(GSH) and hepatic pathological examination was observed with HE coloration. Results Periplaneta American and its different extracts can decrease liver and spleen index( P<0.05,P<0.01) and the activity of ALT, AST(P<0.05,P<0.01) in serum,and MDA(P<0.05,P<0.01)in liver. Moreover, it could enhance the SOD and GSH activity(P<0. 05,P<0.01)in liver tissues and thus relieved liver pathological injury,the efficacy of Periplaneta American and its different extracts existed differences. Conclu-sion Periplaneta American and its extracts have protective effects on acute immunological liver injury in mice,and the protozoa and water extracts better than alcohol extracts or alcohol-water double extracts.关键词
美洲大蠊/刀豆蛋白A/免疫性肝损伤/保护作用Key words
Periplaneta American/concanavalin A/immunological liver injury/protective effects分类
医药卫生引用本文复制引用
张鹏,王佳佳,方海明,程启闰,章礼久..美洲大蠊及其不同提取物对急性免疫性肝损伤保护作用的比较[J].安徽医科大学学报,2014,(1):59-62,63,5.基金项目
安徽省高校自然科学基金(编号:KJ2012A149) （编号:KJ2012A149）
安徽医科大学博士启动科研基金(编号：XJ201005) （编号：XJ201005）
安徽医科大学校科研基金(编号:2011xkj008) （编号:2011xkj008）
