安徽医科大学学报Issue(1)：88-91,4.
右美托咪定对胃癌根治术中瑞芬太尼复合丙泊酚全麻药量及麻醉效果的影响
Evaluation of dexmedetomidin in general anesthesia undergoing Gastrectomy with remifentanil and propofol in dosage and effect
摘要
Abstract
Objective To investigate the effect of hemodynamics, the amount of anesthetic, sedation and analgesia perioperative administered dexmedetomidine in gastrectomy in general anesthesia. Methods Forty patients ( ASAI~II) scheduled for elective gastrectomy under general anesthesia were enrolled in this study. All patients were randomly divided into two groups:dexmedetomidine group ( group D) and control group ( group C) . In group D, 0 . 6 μg/kg of the loading dose dexmedetomidine was administered intravenously by micro-pump for within 15 mi-nutes before induction of anesthesia, then 0.4 μg/(kg·h) was maintained until the 40th min end of surgery. While in group C, the same volume of normal saline was given by the same way. The parameters of BIS, MAP and HR were recored before dexmedetomidine or normal saline infused intravenously ( T1 ) , before the induction of an-esthesia (T2), immediately after intubation ( T3 ), 1min after intubation ( T4 ), immediately after skin incision ( T5 ) , immediately after operation exploration ( T6 ) , immediately after extubation ( T7 ) . The parameters were re-corded such as the amount of propofol and remifentanil, Ramsay and VAS score within four hours after operation. Results Compared to those at T1 and group C, BIS scale of group D at T2 showed significantly decrease ( P <0.01). MAP, HR in group C had a significant increase than those in the group D at T2,T4 ~T7(P<0.05 or P<0.01 ) . Propofol and remifentanil consumption in group D were less than those in group C ( P<0.05 ) . 1 h and 4 h after operation, the Ramsay score in group D was significantly higher than that in group C, the VAS score in group D was significantly lower than that in group C ( P<0.05 ) . Conclusion The application of dexmedetomi-dine in general anesthesia can produce significant sedation, improve the effect of analgesia, reduce the amount of anesthetic and postoperative discomfort.关键词
右美托咪定/全身麻醉/胃癌根治术/镇静/镇痛Key words
dexmedetomidine/general anesthesia/gastrectomy/sedation/analgesia分类
医药卫生引用本文复制引用
王红仙,张野,李云,王斌..右美托咪定对胃癌根治术中瑞芬太尼复合丙泊酚全麻药量及麻醉效果的影响[J].安徽医科大学学报,2014,(1):88-91,4.基金项目
安徽医科大学校基金(编号:2010xkj098) （编号:2010xkj098）
