安徽医科大学学报Issue(2)：248-250,251,4.
超声评价早期原发性高血压患者血管内皮功能和颈动脉内-中膜厚度及其相关性研究
Detection of endothelial function and carotid arterial intima-media thicknessin in patients with early essential hypertension using ultrasound
摘要
Abstract
Objective To access the brachial artery endothelium dependent dilation and the carotid arterial intima-media thickness in patients with early essential hypertension(EH) and to analyze the correlation between them. Methods The brachial artery diameter at basic stage, the brachial artery diameter under reactive hyperemia condi-tion,the brachial artery diameter response to nitroglycerin and the carotid arterial intima-media thickness were measured by high frequency ultrasonography in 35 patients with EH and in 30 normal control subjects. To analyse the correlation between the brachial artery endothelium dependent dilation and the carotid arterial intima-media thickness in patients with early essential hypertension . Results There had significant difference between the two groups in the brachial artery diameter at basic stage(P<0.05). The increased percentage of the brachial artery di-ameter under reactive hyperemia condition in patients with EH decreased significantly compared with normal control subjects ( P<0.01 ) . There was no significant difference between the changes in the two groups in response to ni-troglycerin(P>0.05). The IMT in patients with EH diagnosed increased significantly (P<0.05). The rate of the carotid atheromatous plaque had no significant difference from the normal control group(P>0.05). The increased percentage of the brachial artery diameter under reactive hyperemia condition in patients with EH showed a signifi-cant negative correlation with the carotid arterial IMT(r= -0.646,P<0.01). Conclusion Endothelium depend-ent dilation is impaired in patients with EH. The IMT increases obviously compared with the normal control sub-jects. The endothelium dependent dilation in patients with EH shows a significant negative correlation with the IMT.关键词
原发性高血压/血管内皮功能/颈动脉内-中膜厚度/高频超声Key words
essential hypertension/endothelium dependent dilation/carotid arterial intima-media thickness/high frequency ultrasound分类
医药卫生引用本文复制引用
帅秀芳,郑慧,王邦宁,江洁,靳松,姚文,姚翀,李晓金,王迪..超声评价早期原发性高血压患者血管内皮功能和颈动脉内-中膜厚度及其相关性研究[J].安徽医科大学学报,2014,(2):248-250,251,4.基金项目
安徽省高校自然科学基金重点项目(编号:KJ2013A166) （编号:KJ2013A166）
