安徽医科大学学报Issue(2)：258-261,4.
胃癌中β-catenin、ki67与Her-2/Neu的关系及临床意义
The correlation of β-catenin,ki67 and Her-2/Neu in gastric cancer and the clinical significance
摘要
Abstract
Objective To study the relationship between the protein expression of β-catenin,ki67 and Her-2/Neu with the clinical pathologic characteristics of gastric cancer,and the correlation toβ-catenin and ki67 of the protein expression and gene conditions of Her-2/Neu. Methods Detected the protein expression of β-catenin,ki67 and Her-2/Neu by immunohistochemistry ( SP method) in 101 gastric cancer samples and the gene conditions of Her-2/Neu by fluorescence in situ hybridization ( FISH) . Results The protein expression of β-catenin,ki67 and Her-2/Neu had close relationship with the clinical pathologic characteristics of gastric cancer.β-catenin and ki67 had obvi-ous correlation to the differentiation, infiltration and lymphatic metastasis of the gastric cancer (P<0. 05). ki67 had close relationship with the TNM staging of gastric cancer ( P<0 . 05 ) . Her-2/Neu had close relationship with the differentiation and TNM staging of gastric cancer ( P<0 . 05 ) , but had no relationship with the infiltration and lymphatic metastasis of the gastric cancer. The protein expression of ki67 had obvious positive correlation to the pro-tein expression and gene amplification conditions of Her-2/Neu ( rprotein =0.567, P <0.05;rgene =0.304, P <0.05). Conclusion Association detection of β-catenin,ki67 and Her-2/Neu can be used as the reliable indexes in the process of understanding the biological behavior of gastric cancer,and gastric diagnosis and prognosis judge-ment and ki67 can be used as the reference in preliminary screening the gene amplification conditions of Her-2/Neu,which may have some significance in elevating the detection efficiency of Her-2/Neu gene amplification, re-ducing the detection material waste and guiding the clinical targeted therapy.关键词
胃癌/β-catenin/ki67/Her-2/Neu/免疫组化/荧光原位杂交/肿瘤标志物Key words
gastric cancer/β-catenin/ki67/Her-2/Neu/immunohistochemistry/fluorescence in situ hybridiza-tion/tumor marker分类
医药卫生引用本文复制引用
侯宝洲,孙剑经,赵秀芳,白睿,韩世强..胃癌中β-catenin、ki67与Her-2/Neu的关系及临床意义[J].安徽医科大学学报,2014,(2):258-261,4.基金项目
河北省科学技术研究与发展指导计划项目(编号:072761261) （编号:072761261）
