安徽医科大学学报Issue(2)：262-264,3.
IHC和FISH检测乳腺癌HER-2与ER、PR、淋巴结转移的相关性
IHC and FISH detection of HER-2 and ER, PR in breast cancer, correlation with lymph node metastasi
摘要
Abstract
110 specimens of modified radical mastectomy were treated with fluorescence in situ hybridization and immunohistochemistry, on a comparative analysis. Results showed that positive expression ( ) rate of HER-2 pro-tein in specimens of positive expression of ER and PR detected by IHC was lower significantly than that in speci-mens of negative expression of ER and PR ( 28.36%,37.84% vs 74.42%,63.89%); gene amplification rate in specimens of positive expression of ER and PR detected by FISH was lower significantly than that in specimens of negative expression of ER and PR ( 22.39%,24.32% vs 46.51%, 47.22%); positive expression ( ) rate of HER-2 protein with lymph node metastasis was higher significantly than that without lymph node metastasis ( 62.86% vs 38.67%);gene amplification rate of HER-2 with lymph node metastasis was 38.10%,and gene am-plification rate of HER-2 without lymph node metastasis was 27.94%,so the differences were not statically signifi-cant(P>0.05).关键词
HER-2/IHC/FISH/ER/PR/淋巴结转移Key words
HER-2/IHC/FISH/ER/PR/lymph nodes metastasis分类
医药卫生引用本文复制引用
周海丰,范玉宏,武雪亮,孙喜斌,王立坤,梁晚平,刘运江..IHC和FISH检测乳腺癌HER-2与ER、PR、淋巴结转移的相关性[J].安徽医科大学学报,2014,(2):262-264,3.基金项目
河北省科技厅指导性计划(编号:08276101D-70) （编号:08276101D-70）
