安徽医科大学学报Issue(3)：287-290,4.
天麻素改变大鼠窦房结细胞和心房肌细胞的电生理活动
Changes of electrophysiological profiles of rat myocardial cells after perfusing with Gastrodin
摘要
Abstract
Objective To record the myocardial cell bioelectric activities and explore electrophysiological profiles of Gastrodin on rat myocardial cells. Methods Sinoatrial node cells and atrial myocytes isolated from 50 SD rats were used in this study to characterize the effect of Gastrodin on their electrophysiological profiles with intracellular recording approaches. Results In the present experimental conditions, the bioelectric activities of sinoatrial node and atrial myocytes were truly recorded and we found that Gastrodin significantly accelerated AP frequency and Vmax 4 of sinoatrial node cells and shortened APD90 of atrial myocytes. Conclusion The experimental conditions of recording the bioelectric activities of myocardial cells in vitro are relatively mature. Gastrodin can affect the elec-trical activity of myocardial cells in vitro and the effects of Gastrodin may be related to inhance the permeability of T-Ca2+ channels and promote the opening of KATP.关键词
天麻素/心房肌细胞/窦房结细胞/动作电位Key words
Gastrodin/atrial myocytes/sinoatrial node cells/action potential分类
医药卫生引用本文复制引用
王飞,位凯,沈兵,王烈成,孔德虎,胡金兰..天麻素改变大鼠窦房结细胞和心房肌细胞的电生理活动[J].安徽医科大学学报,2014,(3):287-290,4.基金项目
安徽省教育厅科研课题(编号:2006KJ362b) （编号:2006KJ362b）
校级优秀青年教师后备人选基金资助(编号:2009A028) （编号:2009A028）
