安徽医科大学学报Issue(3)：323-326,4.
滁菊总黄酮的镇痛作用及与一氧化氮和前列腺素E2的关系
The relationship between analgesic effect of total flavonoids of Chuzhou chrysanthemum and nitric oxide and prostaglandin E2
摘要
Abstract
Objective To study the analgesic effect of total flavone of Chuzhou chrysanthemum ( TFCC ) and its mechanism. Methods Writhing test, warm bath method, formalin method, the hot plate test were used to examine analgesic effect on mice, and serum and brain tissue nitric oxide( NO) and prostaglandin E2 ( PGE2 ) contents were determinated the Griess method and ultraviolet spectrophotometry. Results Intragastrical administration of TFCC 100 mg/kg and 200 mg/kg could significantly reduce the writhing number in mice,II-phase pain in formaldehyde induced pain in mice, and prolonged the mice hot plate licking foot response latency and hot shrinkage tail reaction time. Intracerebroventricular injection TFCC 5 mg/kg and 10 mg/kg could significantly inhibit the writhing number in mice. TFCC 100 mg/kg and 200 mg/kg significantly increased mice serum and brain NO contents, and reduced PGE2 contents. Conclusion TFCC has obvious analgesic effect, and its analgesic mechanism may be related to the promation of NO release and the inhibition of PGE2 .关键词
滁菊总黄酮/镇痛/一氧化氮/前列腺素E2Key words
total flavonoids of Chuzhou chrysanthemum/analgesic/nitric oxide/prostaglandin E2分类
医药卫生引用本文复制引用
张蓓蓓,陈志武,罗胜勇,马征..滁菊总黄酮的镇痛作用及与一氧化氮和前列腺素E2的关系[J].安徽医科大学学报,2014,(3):323-326,4.基金项目
国家自然科学基金(编号:81173596) （编号:81173596）
