安徽医科大学学报Issue(3)：370-373,4.
GSTM1、GSTT1基因多态性与新疆维吾尔族慢性阻塞性肺疾病易感性的关系
Association of genetic polymorphism GSTM1 and GSTT1 with susceptibility to chronic obstructive pulmonary disease in Xinjiang Uighur population
摘要
Abstract
Objective To investigate the association of genetic polymorphism GSTM1 and GSTT1 with susceptibility to chronic obstructive pulmonary disease ( COPD ) in Xinjiang Uighur population. Methods The genotypes of GSTM1 and GSTT1 were determined by multiplex polymerase chain reaction ( mPCR ) in patients with COPD ( COPD group) and healthy control group, and analyzed its susceptibility. Results The frequencies of GSTM1 null genotype, GSTT1 null genotype, GSTM1 and GSTT1 homozygous null genotype were significantly higher than that of the control one, respectively. There were significant differences of genetic polymorphism GSTM1 and GSTT1 be-tween the two groups. After adjustment for sex, age, smoking history, the GSTM1 and GSTT1 gene homozygous de-letion alone were risk factors for COPD ( OR=2.22 ,95%CI:1.16~4.25 , P=0.016;OR=2.47 , 95% CI:1 . 23~4 . 97 , P =0.011 ) , GSTM1 and GSTT1 at the same time as a risk factor for homozygous deletion type was COPD. Conclusion Our results suggest that there are associations of genetic polymorphism of neither GSTM1 nor GSTT1 with susceptibility to COPD.关键词
慢性阻塞性肺疾病/多态性/谷胱甘肽 S-转移酶M1/谷胱甘肽S-转移酶T1Key words
chronic obstructive pulmonary disease/polymorphisms/glutathione S-transferase M1/glutathione S-transferase T1分类
医药卫生引用本文复制引用
王妨娥,凌敏,白杰,苟安栓,钱建辉,赵宗峰..GSTM1、GSTT1基因多态性与新疆维吾尔族慢性阻塞性肺疾病易感性的关系[J].安徽医科大学学报,2014,(3):370-373,4.基金项目
中华医学会慢性呼吸道疾病专项基金(2007年)(编号:07010160024) （2007年）
