按摩与康复医学Issue(12)：30-31,32,3.
冠心病患者氧化型低密度脂蛋白及同型半胱氨酸水平研究
Study on the Levels of Oxidized Low Density Lipoprotein and Homocysteine in Patients with Coronary Heart Disease
摘要
Abstract
Objective:To observe the relationship of oxidized low density lipoprotein (OX-LDL-C), homocysteine (HCY) in plasma and stenosis de-gree of coronary, and to investigate the possibility of regarding them as non-invasive predictors for severity of coronary lesions. Methods:According to the result of coronary angiography, 86 cases of suspected coronary heart disease patients were divided into CHD group and NCHD group, then again divided patients of CHD group into single-vessel group, double-vessel group and multi-vessel group, analyzed the relationship of OX-LDL-C, HCY in plasma and stenosis degree of coronary, tested the ROC curve for diagnosis of coronary heart disease, and determined the critical value of OX-LDL-C and HCY for diagnosis of coronary heart disease. Results:The levels of OX-LDL-C and HCY in plasma of CHD group were both higher than those of NCHD group (P<0.05);the levels of OX-LDL-C and HCY in plasma was increasing with the increasing of the lesion branches, which differences were statistically significant (P<0.05);it had a high sensitivity and specificity for diagnosis of coronary heart disease when the critical val-ue of OX-LDL-C was 527.5μg/L and HCY was 13.5μmol/L. Conclusion:The levels of OX-LDL-C and HCY in plasma have high value in diagno-sis of coronary herat disease, which can be used for early risk stratification, helpful to identify the high-risk patients with coronary heart disease time-ly, and decrease the mortality of coronary heart disease.关键词
冠心病/氧化型低密度脂蛋白/同型半胱氨酸/血浆/诊断/相关性Key words
coronary heart disease/oxidized low density lipoprotein (OX-LDL-C)/homocysteine (HCY)/plasma/diagnosis/relationship分类
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陈美玉,黄武..冠心病患者氧化型低密度脂蛋白及同型半胱氨酸水平研究[J].按摩与康复医学,2013,(12):30-31,32,3.基金项目
2011年佛山市医学科学技术研究计划项目，编号2011092 （）
