按摩与康复医学Issue(12)：114-116,117,4.
姜黄素和胡椒碱溶解度和表观油水分配系数的测定
Determination of the Solubility and Apparent Oil-water Partition Coefficient of Curcumin and Piperine
摘要
Abstract
Objective:To determine the solubility, apparent oil-water partition coefficient and the pH value of its implications of curcumin and piper-ine, which can provide reference for novel exploitation. Methods:The concentrations of curcumin and piperine and the solubility of them in different organic solvents were determined by HPLC at the same conditions. The determination of curcumin and piperine at different pH conditions apparent solubility, and its apparent oil-water partition coefficient was measured by shake flask. Results:Solubility of Curcumin in ethanol, propylene glycol , glycerol , PEG400 and n-octanol were 0.021 4 g·ml-1, 0.020 1 g·ml-1, 0.010 0 g·ml-1, 0.063 6 g·ml-1 and 0.032 8 g·ml-1, furthermore, the solubil-ity of piperine in ethanol, propylene glycol , glycerol , PEG400 solubility and octanol were 0.0478 g·ml-1, 0.022 0 g·ml-1, 0.012 8 g·ml-1, 0.061 9 g·ml-1 and 0.044 3 g·ml-1. The apparent oil-water partition coefficient of curcumin and piperine were 4738.609 (Log P=3.675 7) and 72.919 9 (Log P=1.862 8 ) at 25℃, respectively. Conclusions:Curcumin was insoluble in buffer solution at different pH;while piperine having a solubility in a different buffer solution, with gradual increase of pH increases the solubility . Curcumin and piperine are fat-soluble ingredients, difficult to dis-solve in water.关键词
姜黄素/胡椒碱/溶解度/表观油水分配系数/测定Key words
curcumin/piperine/solubility/apparent oil-water partition coefficient/determination分类
医药卫生引用本文复制引用
涂瑶生,付建武,张建军,崔景朝,曾晓会..姜黄素和胡椒碱溶解度和表观油水分配系数的测定[J].按摩与康复医学,2013,(12):114-116,117,4.基金项目
广州市科技计划项目，编号11C36080689；广东省自然科学基金项目，编号S2011010005927, S2011010005928， S2013010012360 （）
