摘要
Abstract
Objective To sum up the clinical experiences and curative effects of preparations of Danshen (Radix Salviae Miltiorrhizae) and Dongchongxiacao (Cordyceps) applied in renal transplantation in 112 patients. Methods The clinical data of 112 patients with renal transplantation were retrospectively analyzed from 2003 to 2007. The patients were randomly divided into treatment group (n=56) and control group (n=46). The two groups were treated with immunosuppressant and treatment group was additionally given preparations of Danshen and Dongchongxiacao. The survival rates of both patients and kidneys after 1 year, 3 years and 5 years, postoperative rejection, complications, major causes of death, and abnormal renal function were observed respectively. The treatment of chronic allograft nephropathy (CAN) was observed too. Results The survival rates of both patients and kidneys were 96.4%, 85.7%and 74.1%in 112 patients, respectively, after 1 year, 3 years and 5 years. There was 1 Objective To sum up the clinical experiences and curative effects of preparations of Danshen (Radix Salviae Miltiorrhizae) and Dongchongxiacao (Cordyceps) applied in renal transplantation in 112 patients. Methods The clinical data of 112 patients with renal transplantation were retrospectively analyzed from 2003 to 2007. The patients were randomly divided into treatment group (n=56) and control group (n=46). The two groups were treated with immunosuppressant and treatment group was additionally given preparations of Danshen and Dongchongxiacao. The survival rates of both patients and kidneys after 1 year, 3 years and 5 years, postoperative rejection, complications, major causes of death, and abnormal renal function were observed respectively. The treatment of chronic allograft nephropathy (CAN) was observed too. Results The survival rates of both patients and kidneys were 96.4%, 85.7%and 74.1%in 112 patients, respectively, after 1 year, 3 years and 5 years. There was 1 case with accelerated rejection, 9 cases with acute rejection, 8 with acute tubular necrosis, 1 with urinary fistula, and 11 missed follow-up. There were totally 11 cases died, among them 3 died in perioperative period and 8 died with normal renal function including 5 died of cancer (4.5%). The comparison of survival rates of both patients and kidneys after 5 years showed that the survival rate was 82.1% (46/56) in treatment group and 80.4% (37/46) in control group (P>0.05), and incidence of abnormal renal function was 16.1%(9/56) in treatment group and 41.3%(19/46) in control group (P<0.01). There were 28 cases diagnosed as CAN in two groups. At the same time of reducing the dose of immunosuppressant or changing it, these cases were given intravenous drip of Danshenfen Injection for 2 weeks and the level of serum creatinine decreased averagely by (84.3 ± 24.5)μmol/L. Conclusion The additional application of the preparations of Danshen and Dongchongxiacao besides of routine anti-rejection treatment has a good curative effect in the patients with renal transplantation, and similarly preparation of Danshen has the therapeutic effect on CAN.关键词
肾移植/丹参/百令胶囊/存活率Key words
renal transplantation/Danshen (Radix Salviae Miltiorrhizae)/Bailing Capsules/survival rate分类
中医学
