Abstract
Objective To observe the curative effect of the therapies of tonifying qi and replenishing blood, and dispelling dampness and freeing collateral vessels on rheumatoid arthritis (RA, type of deficiency of qi and blood and type of cold-dampness obstruction). Methods The patients (n=50) with RA (type of deficiency of qi and blood and type of cold-dampness obstruction) were randomly divided into treatment group and control group (each n=25). The control group was orally given leflunomide pills and Zhengqingfeng Tongning Pian, and treatment group was orally given leflunomide pills and Chinese medicinal with the actions of tonifying qi and replenishing blood, and dispelling dampness and freeing collateral vessels. A therapeutic course was 4 weeks. The curative effect, integral changes of symptom and signs, ESR, CRP, RF and PLT, and quality of life were compared between two groups. Results In treatment group, there were 3 cases (12%) with significant effect, 10 (40%) with advanced effect, 8 (32%) with effect and 4 (16%) without effect, and the total effective rate was 84%. In control group, there was 1 case (4%) with significant effect, 6 (24%) with advanced effect, 10 (40%) with effect and 8 (32%) without effect, and the total effective rate was 68%. The result of Ridit analysis showed that U=-2.086, P=0.043 and P<0.05. After treatment, the scores of symptoms, including arthralgia, arthroncus, joint tenderness, morning stiffness time, aversion to cold, preferring warmth, lack of strength, short of breath, complexion, muscle numbness, dreaminess and forgetfulness, were lower in treatment group than those before treatment (P<0.05). The scores of arthralgia, arthroncus, joint tenderness, morning stiffness time, aversion to cold, preferring warmth, lack of strength, short of breath and complexion were lower (P<0.05), and those of muscle numbness, dreaminess and forgetfulness had no statistical significance (P>0.05) in control group compared with those before treatment. The D-value of symptom scores before and after treatment had statistical significance (P<0.05) between two groups. After treatment, the levels of ESR, CRP, RF and PLT decreased in two groups (P<0.05), and D-value of laboratory indexes before and after treatment had statistical significance (P<0.05) between two groups. The scores of quality of life decreased (P<0.05) in two groups than those before treatment, and D-value of scores of quality of life before and after treatment had statistical significance (P<0.05) between two groups. Conclusion The therapies of tonifying qi and replenishing blood, and dispelling dampness and freeing collateral vessels have good curative effect on RA (type of deficiency of qi and blood and type of cold-dampness obstruction).关键词
类风湿关节炎/中医证型/中药治疗Key words
rheumatoid arthritis/TCM syndrome types/treatment with Chinese medicinal分类
医药卫生
