磁共振成像Issue(1)：35-39,5.DOI:10.3969/j.issn.1674-8034.2014.01.008
MRI对Graves病患者131I核素治疗效果的早期评价
Early evaluation of 131I nuclide therapeutic effect in Graves’ disease patients by MRI
王忠伟 1陈娇 1刘冰 1韩伟 1郑薇 2孟召伟 2张桂芝 2孙浩然1
作者信息
- 1. 天津医科大学总医院放射科，天津300052
- 2. 天津医科大学总医院核医学科，天津300052
- 折叠
摘要
Abstract
Objective:To evaluate the early effect of 131I nuclide therapy in Graves’ disease by MRI. Materials and Methods: MRI was performed in 18 GD patients before and at 1, 3 months after 131I nuclide therapy respectively. According to the follow-up thyroid function laboratory results at 3 months, the enrolled GD patients were divided into effective group (n=9) and ineffective group (n=9). Overall thyroid volume and apparent diffusion coefifcient (ADC) values were measured blindly and the changes of volumes and ADCs were compared longitudinally in both groups. Results:Compared with GD patients before 131I nuclide therapy, the thyroid volume decreased significantly in effective group (P<0.01) in the patients one month after therapy, while there was no change in ineffective group (P=0.07), and there was no change for the average thyroid ADC values in both groups (P=0.54, 0.27). The thyroid volume decreased signiifcantly in both effective group (P<0.01) and ineffective group (P<0.05) in GD patients three months after therapy compared with patients before therapy;the average thyroid ADC values decreased in effective group (P<0.05), however, there was no change in ineffective group (P=0.46). The thyroid volume decreased signiifcantly in effective group (P<0.05) but there was no change in ineffective group (P=0.20) three months after therapy compared with that of one month after therapy, and there was no change for the average thyroid ADC values in both groups (P=0.53, 0.08) between three and one months after therapy. Conclusion:The overall thyroid volume and the average ADC values could demonstrate early response after 131I nuclide therapy in Graves’ disease patients.关键词
格雷夫斯病/磁共振成像,弥散/碘同位素/随访研究Key words
Graves’ disease/Diffusion magnetic resonance imaging/Iodine isotopes/Follow-up studies分类
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王忠伟,陈娇,刘冰,韩伟,郑薇,孟召伟,张桂芝,孙浩然..MRI对Graves病患者131I核素治疗效果的早期评价[J].磁共振成像,2014,(1):35-39,5.
