重庆医学Issue(28)：3342-3343,3346,3.DOI:10.3969/j.issn.1671-8348.2013.28.003
非痴呆性血管性认知功能障碍患者ChAT和CHE活性变化及其临床意义
Study of the activities of ChAT and CHE in patients with non-dementia vascular cognitive impairment
摘要
Abstract
Objective To study of the activities of choline acetyltransferase (ChAT ) and cholinesterase(CHE) in non-dementia vascular cognitive impairment (VCIND)patients ,and explore its mechanism .Methods Sixty-one patients with VCIND were select-ed as the research group (which accord with Rockwood diagnostic criteria for cognitive dysfunction but not meet the NINDS-ARI-IEN diagnostic criteria for vascular dementia)and 75 healthy people in the same period as the control group .Venous blood was col-lected in the early morning and serum was separated in both of the two groups .The activities of ChAT and CHE were detected by spectrophotometric method .Results The activity of ChAT in the research group(120 .94 ± 23 .93) U/mL was increased significant-ly than the control group(64 .88 ± 12 .23) U/mL(P<0 .01) ,while there was no significant difference in CHE activity between the two groups(P>0 .05) .Conclusion The increased activity of ChAT in VCIND patient and enhance the synthesis of acetylcholine , which may be a compensatory mechanism of VCIND .关键词
认知障碍/胆碱乙酰化酶/胆碱酯酶Key words
cognition disorders/choline acetyltransferase/cholinesterase引用本文复制引用
王凡,李毅,肖雁,徐源,刘健,官志忠..非痴呆性血管性认知功能障碍患者ChAT和CHE活性变化及其临床意义[J].重庆医学,2013,(28):3342-3343,3346,3.基金项目
国家自然科学基金资助项目（81260173），贵州省科技厅基金项目（黔科合 J字2012［2055］）。 （）
