重庆医学Issue(28)：3357-3359,3.DOI:10.3969/j.issn.1671-8348.2013.28.009
小剂量罗红霉素对吸烟哮喘患者气道炎症的影响
Influence of treating with roxithromycin on airway inflammation in patients with asthma who smoke
摘要
Abstract
Objective To investigate the influence and effect of treating with low dose roxithromycin on airway inflammation in asthma who have been smoking patients .Methods Forty-six patients with mild to moderate asthma who had been smoking were assigned to group A and group B randomly .The patients in group A received inhaling salmeterol/fluticasone(50/250 μg) ,one puff bid ,2 times/day .The patients in group B treated with oral roxithromycin dispersible tablet 0 .15 g/d combining with inhaling salme-terol/fluticasone(50/250 μg) ,one puff bid ,2 times/day .The patients of two groups had been treated for 4 weeks .The lung func-tion ,cells and interleukin-8(IL-8) in induced sputum of patients in the two groups were measured before and after treatment .Results There was negative correlation between the FEV 1% and the number of eosinophile granulocyte ,neutrophil and the concentration of IL-8 in induced sputum of the patients(P<0 .01) .The number of neutrophil ,eosinophile granulocyte and the level of IL-8 of the patients in group B decreased more than those in the group A after 4 weeks of treatment(P<0 .05) .Furthermore the PEF and FEV1% of the patients in group B were ameliorated significantly than those in group A (P<0 .01) .Conclusion The treatment of roxithromycin combining with salmeterol/fluticasone on patients with asthma who smoke can not only reduce the number of eosino-phile granulocyte ,neutrophil and the level of IL-8 in induced sputum significantly ,but also ameliorate the PEF and FEV1% of them significantly .关键词
罗红霉素/哮喘/吸烟/炎症/影响Key words
roxithromycin/asthma/smoke/inflammation/impact引用本文复制引用
郑小珍,刘积锋,钟蔚,吴文斌,檀月芳,黄玉仕..小剂量罗红霉素对吸烟哮喘患者气道炎症的影响[J].重庆医学,2013,(28):3357-3359,3.基金项目
广西卫生厅自筹经费科研课题（Z2007355）。 （）
