重庆医学Issue(28)：3413-3415,3.DOI:10.3969/j.issn.1671-8348.2013.28.031
贵州3个民族亚甲基四氢叶酸还原酶基因的遗传多态性
Methylenetetrahydrofolate reductase polymorphism in three nationality in Guizhou
摘要
Abstract
Objective To identify the distribution feature of methylenetetrahydrofolate reductase (M T HFR) gene polymorphism of Buyi ,Dong ,Miao nationality in Guizhou .Methods The MTHFR(677 and 1 298) genotypes of Buyi ,Miao and Dong healthy indi-viduals were determined by TaqMan-MGB probe genotyping method and constructed haplotypes .Results There were significant difference of MTHFR 677C/T genotype and allele frequencies among 3 groups(P<0 .05) ,There was significant difference of geno-type between Buyi and Miao nationality ,and there were significant differences of genotype frequencies in Buyi nationality and Dong and Miao nationality(P<0 .01) .There were no differences of MTHFR 1298A/C genotype frequencies among Buyi ,Dong and Miao nationality(P> 0 .05) .Buyi nationality had the lowest frequency in double wild homozygous type (677CC/1298AA) ,677TT/1298CC double mutation homozygous and 677TT/1298AC combination in above three minorities was not found .There were linkage disequilibrium between 677C/T and 1298A/C in Buyi and Miao nationality .Conclusion The genotypes frequencies of MTHFR 677T T/1298AC are significant differences among different regions and different ethnic groups .关键词
亚甲基四氢叶酸还原酶/基因多态性/少数民族Key words
methylenetetrahydrofolate reductase/polymorphism/minority groups引用本文复制引用
张婷,谢渊,李毅,单可人,官志忠..贵州3个民族亚甲基四氢叶酸还原酶基因的遗传多态性[J].重庆医学,2013,(28):3413-3415,3.基金项目
“十二五”国家科技支撑计划（2013BAI05B03）；贵州省社会发展攻关项目（黔科合 SY［2010］3001号）；贵州省科技厅科技计划课题资助项目 （）
