重庆医学Issue(32)：3863-3866,4.DOI:10.3969/j.issn.1671-8348.2013.32.005
腹水CD64指数对失代偿期肝硬化并发自发性细菌性腹膜炎的诊断价值
Significance of the ascites CD 64 index in patients with decompensated cirrhosis complicated with spontaneous bacterial peritonitis
刘光亮 1王娜 1陈春波 2陶鹏 3张大志 1周智 1胡鹏 1孙航 1刘杞3
作者信息
- 1. 重庆医科大学附属第二医院感染科 400010
- 2. 重庆医科大学病毒性肝炎研究所 400042
- 3. 重庆医科大学病毒性肝炎研究所 400042
- 折叠
摘要
Abstract
Objective To detect the ascites CD64 index of patients with decompensated cirrhosis ,and explore the value in the di-agnosis of spontaneous bacterial peritonitis (SBP) .Methods Decompensated cirrhosis with ascites patients were divided into non-SBP group ,SBP suspected group and SBP diagnosed group .Two control groups were composed of patients with ascites culture pos-itive and non-SPB group .SBP suspected group were further grouped according to abdominal pain and the percentage of peripheral blood neutrophils .The CD64 index was detected by flow cytometry .Compared the difference of ascites CD64 index after treatment , and analyzed diagnosis performance of procalcitonin in human peripheral blood and ascites white blood cell count of SBP .Results The level of the ascites CD64 index was significantly higher in SBP diagnosed group (179 .39 ± 65 .56)and SBP suspected group (115 .49 ± 58 .42)than that of non-SBP group(26 .88 ± 26 .05)(P<0 .01) .The differences of the ascites CD64 index between SBP suspected associated with abdominal pain group and SBP suspected associated with painless group was not statistically significant (P>0 .05) .The level of the ascites CD64 index in SBP suspected with percentage of peripheral blood neutrophils elevated group was increased significantly than non-elevated group(P<0 .05) .CD64 index level in effective treatment group was significantly lower than the ineffective treatment group(P<0 .01) .The area of the ascites CD64 index under the curve was greater than procalcitonin in human peripheral blood and ascites WBC count ,and had a higher sensitivity and specificity .Conclusion The detection process of the ascites CD64 index is fast and with less influential factors ,which provides a new choice for the clinical diagnosis of SBP .关键词
肝硬化/腹水/流式细胞术/自发性细菌性腹膜炎/CD64指数Key words
liver cirrhosis/ascites/flow cytometry/spontaneous bacterial peritonitis/CD64 index引用本文复制引用
刘光亮,王娜,陈春波,陶鹏,张大志,周智,胡鹏,孙航,刘杞..腹水CD64指数对失代偿期肝硬化并发自发性细菌性腹膜炎的诊断价值[J].重庆医学,2013,(32):3863-3866,4.
