重庆医学Issue(32)：3926-3928,3.DOI:10.3969/j.issn.1671-8348.2013.32.030
不同剂量的食用白酒对大鼠心脏结构与功能影响的研究
Effects of different dose of edible liquor on cardiac structure and function in rats
摘要
Abstract
Objective To investigate the effects of different dose of edible liquor on cardiac structure and function in rats ,and explore its underlying mechanisms .Methods 54 male SD rats were randomly divided into saline group ,alcohol group ,liquor group , each group were further divided into low-,middle-and high-dose groups .After 12 weeks of feeding ,left ventricular pressure was de-termined ,and left ventricular pressure amplitude and indexes of HW /BW were calculated .Myocardial fibrosis was observed by Masson staining ,AngⅡ content of myocardial tissue were detected by ELISA ,and ACE and ACE2 mRNA expressions were detec-ted by RT-PCR ,respectively .Results Left ventricular pressure amplitude and HW/BW index were increased by both liquor and al-cohol .The myocardial cell turbidity ,degeneration ,hyperplasia of fibrous tissue change were gradually worsened ,and the AngⅡ con-tents and the ACEmRNA expressions of the myocardial tissue were also increased by both liquor and alcohol .The ACE2 mRNA ex-pression of the myocardial tissue were higher by low-dose liquor and alcohol ,while the ACE2 mRNA expression of the myocardial tissue were lower by middle-and high-dose liquor and alcohol .Conclusion Long-term alcohol consumption can damage the balance of cardiac ACE and ACE2 ,causing the increase of ACE ,AngⅡ and the decrease of ACE2 ,resulting in myocardial fibrosis ,whose degree is related to the amount of alcohol consumption and drinking history .关键词
血管紧张素Ⅱ/肽基二肽酶A/心肌组织/食用白酒Key words
angiotensinⅡ/peptidyl-dipeptidase A/myocardial tissue/edible liquor引用本文复制引用
刘爱东,蒋慧,牛晨,田虹,潘贵书..不同剂量的食用白酒对大鼠心脏结构与功能影响的研究[J].重庆医学,2013,(32):3926-3928,3.基金项目
贵州省科技厅资助项目（黔科合重大专项字［2010］6004号）；贵州省遵义市科技局资助项目（遵市科合社重字［2009］1号）。 （）
