重庆医学Issue(33)：3995-3998,4001,5.DOI:10.3969/j.issn.1671-8348.2013.33.007
冠状动脉内注射阿昔单抗用于经皮冠状动脉介入治疗的系统评价
Intracoronary abciximab administration for patients undergoing percutaneous coronary intervention:a meta-analysis of randomized trials
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of intracoronary abciximab administration as compared to intravenous in percutaneous coronary intervention (PCI) .Methods A search was conducted in PubMed ,EMBASE ,OVID ,CBM , CNKI and VIP for the randomized controlled trials (RCTs)of intracoronary abciximab administration versus intravenous in PCI , from the date of their establishment to September 30 ,2013 ,and the domestic relevant papers published in recent 1 year were also searched manually ,the bibliographies of the included studies were searched too .According to the criteria of the cochrane Hand-book ,two reviewers evaluated the quality of the included RCTs and extracted data independently ,and then the extracted data were analyzed by using RevMan 5 .1 software .Results 8 RCTs involving 10 articles with 4 150 patients who treated with PCI were in-cluded .The results of meta-analysis showed that :(1) Compared intravenous administration and intracoronary abciximab administra-tion ,there were no significant differences in the two groups for the major adverse cardiovascular event (MACE) and the mortality (OR=0 .78 ,95% CI 0 .54-1 .14 ,P=0 .20) ,(OR=0 .56 ,95% CI 0 .24-1 .30 ,P=0 .18) .(2)Compared with intravenous adminis-tration ,intracoronary abciximab administration were not associated with any excess of major bleeding complications :(OR=1 .26 , 95% CI 0 .78-2 .02 ,P=0 .35) .Conclusion Compared with standard abciximab regimen of intravenous bolus ,intracoronary admin-istration had equivalent effects in clinical outcomes in patients undergoing PCI ,and did not increase the incidence of bleeding events .关键词
阿昔单抗/血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂/经皮介入治疗/冠状血管/静脉/Meta分析Key words
abciximab/glycoprotein Ⅱ b/Ⅲ a inhibitors/percutaneous coronary intervention/coronary vessels/veins/Meta-analysis引用本文复制引用
尹晴,张志刚,马亚平,李斌飞..冠状动脉内注射阿昔单抗用于经皮冠状动脉介入治疗的系统评价[J].重庆医学,2013,(33):3995-3998,4001,5.基金项目
国家高技术研究发展计划“863计划”（2011ZX092011-006）。 （）
