重庆医学Issue(33)：4012-4013,4016,3.DOI:10.3969/j.issn.1671-8348.2013.33.013
血浆N末端脑钠肽前体对严重脓毒症和脓毒症休克患者预后判断的价值
The value of prognosis of NT-proBNP in severe sepsis and septic shock patients
李远华 1宋秀婵 1戚应静 1曾沛扬 1吴苏华 1赖志君 1谢树锋1
作者信息
- 1. 广东医学院附属石龙博爱医院ICU，广东东莞523320
- 折叠
摘要
Abstract
Objective To investigate the value of prognosis of NT-proBNP in severe sepsis and septic shock patients .Methods 70 patients with sepsis admitted to our hospital were divided into general sepsis group (n=23) ,severe sepsis group(n=28) and sep-tic shock group(n=19) according to the severity of the disease ,the plasma NT-proBNP ,lactic acid ,C-reactive protein were meas-ured within 1 h after admission ,and calculated the 24 h acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) .Results (1) Plasma NT-proBNP concentration ,lactic acid ,CRP and APACHE Ⅱ score in severe sepsis group ,septic shock group was sig-nificantly higher than that of general sepsis group(P< 0 .05);Plasma NT-proBNP concentration ,CRP and APACHE Ⅱ score in septic shock group was significantly higher than severe sepsis group (P<0 .05) .(2)70 cases of patients with sepsis with 15 cases died and 55 cases survived .Plasma NT-proBNP concentration ,lactate ,CRP and APACHEⅡscore of death patients was significantly higher than the survival patients(P<0 .01) .(3) Plasma NT-proBNP concentration at the time of sepsis patients admitted to hospi-tal with positively correlated to APACHE Ⅱscores(r=0 .528 ,P<0 .01) .Conclusion The plasma NT-proBNP is closely related to the prognosis of patients with sepsis ,early detection of plasma concentration of NT-proBNP helps to evaluate the prognosis of pa-tients w ith sepsis .关键词
脓毒症/N末端脑钠肽前体/脓毒症休克/预后Key words
sepsis/N terminal pro-brain natriuretic peptide/septic shock/prognosis引用本文复制引用
李远华,宋秀婵,戚应静,曾沛扬,吴苏华,赖志君,谢树锋..血浆N末端脑钠肽前体对严重脓毒症和脓毒症休克患者预后判断的价值[J].重庆医学,2013,(33):4012-4013,4016,3.
