重庆医学Issue(34)：4117-4119,3.DOI:10.3969/j.issn.1671-8348.2013.34.005
严重颅脑损伤后血清 GFAP 、UC H-L1与 CT 表现及预后的关系
Relationship between GFAP,UCH-L1 and CT findings and outcome in patients with severe traumatic brain injury
摘要
Abstract
Objective To investigate the relationship between the levels of serum glial fibrillary acidic protein (GFAP) ,ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) ,CT findings and outcome in patients with severe traumatic brain injury .Methods En-zyme linked immunosorbent assay (ELISA) was conducted to detect the serum level of GFAP and UCH-L1 in 62 patients with se-vere traumatic brain injury at the time of 12 h and 36 h after the trauma .CT scans of the brain were obtained within 12 h of injury . Outcome was assessed by glasgow outcome scale (GOS) at 6th month .The relationship between GFAP ,UCH-1 ,CT findings and outcome were analyzed .56 healthy persons were selected as control group .Results The concentrations of serum GFAP and UCH-L1 of patients were significantly higher than those of the control group (P< 0 .05) ;GFAP levels were higher in patients with mass lesions than in those with diffuse injury while UCH-L1 levels were higher in patients with diffuse injury (P< 0 .05) ;the levels of GFAP and UCH-L1 of patients with unfavourable outcome(GOS 1 - 3 scores) were significantly higher than those of patients with favourable outcome(GOS 4 - 5 scores) ,and the concentrations of biomarkers were significantly negatively correlated with outcome . Conclusion Serum levels of GFAP and UCH-L1 are good predictors for severity and outcome in severe traumatic brain injury (TBI) .The levels of GFAP and UCH-L1 could reflect different injury pathways which were different in patients with mass lesions and diffuse injury remarkbly .GFAP and UCH-L1 could provide better characterization of subjects for specific types of cellular dam -age than that obtained with CT alone .关键词
颅脑损伤/神经胶质原纤维酸性蛋白/CT/泛素羧基端水解酶/预后Key words
traumatic brain injury/glial fibrillary acidic protein/CT/ubiqutin carboxy-terminal hydrolase L1/outcome引用本文复制引用
邓健平,孙晓川,刘科..严重颅脑损伤后血清 GFAP 、UC H-L1与 CT 表现及预后的关系[J].重庆医学,2013,(34):4117-4119,3.基金项目
国家临床重点专科建设项目（财社［2011］170号）。 （）
