重庆医学Issue(1)：61-63,66,4.DOI:10.3969/j.issn.1671-8348.2014.01.021
新辅助化疗对局部晚期非小细胞肺癌肿瘤标记物和淋巴细胞亚群的影响
Effect of neoadjuvant chemotherapy on locally advanced non-small cell lung cancer tumor markers and lymphocyte subsets
王纯 1卢宏达1
作者信息
- 1. 湖北省武汉市中心医院北院肿瘤科，武汉430024
- 折叠
摘要
Abstract
Objective To observe and analyze the effect of neoadjuvant chemotherapy on locally advanced non-small cell lung cancer tumor markers and lymphocyte subsets of different pathological type .Methods A total number of 40 NSCLC patients which received neoadjuvant chemotherapy and 20 normal people were selected in our study .To compare the differences of CEA ,CA-125 , CYFRA21-1 and lymphocyte subset in NSCLC pantients with adenocarcinoma or squamous cell carcinoma and the the differences of CEA ,CA-125 ,CYFRA21-1 and lymphocyte subset in patients with different clinical effect .Results (1) The CEA ,CA-125 ,CY-FRA21-1 in pantients with adenocarcinoma or squamous cell carcinoma were both higher than normal people .The CEA level in pa-tients with adenocarcinoma was higher than squamous cell carcinoma ,while the CA-125 and CYFRA21-1 in squamous cell carcino-ma were higher than adenocarcinoma .The CD3+ ,CD4+ ,CD8+ ,CD4+ /CD8+ in pantients with adenocarcinoma or squamous cell carcinoma both had obvious differences with normal people .But there were no obvious differences between patients with adenocarci-noma and squamous cell carcinoma .(2)There were 18 cases of CR+ PR while 22 cases of SD+ PD .The CA-125 and CYFRA21-1 were decreased in patients of squamous cell carcinoma with clinical effective while the CEA and CYFRA 21-1 were decreased in ade-nocarcinoma with clinical effective .The CD3+ ,CD4+ ,CD4+ /CD8+ increased and CD8+ decreased in patients of squamous cell car-cinoma or adenocarcinoma with clinical effective .Conclusion The tumor marker and lymphocyte subsets values had obvious differ-ences in adenocarcinoma and squamous cell carcinoma .Both tumor marker and lymphocyte subsets were useful in diagnosis .关键词
非小细胞肺癌/晚期/新辅助化疗/肿瘤标记物/淋巴细胞亚群Key words
non-small cell lung cancer/advanced/neoadjuvant chemotherapy/tumor marker/lymphocyte subsets引用本文复制引用
王纯,卢宏达..新辅助化疗对局部晚期非小细胞肺癌肿瘤标记物和淋巴细胞亚群的影响[J].重庆医学,2014,(1):61-63,66,4.
