重庆医学Issue(1)：64-66,3.DOI:10.3969/j.issn.1671-8348.2014.01.022
CyclinA2基因5′-UTR多态性与结直肠癌遗传易感性的关系
Association between CyclinA2 gene 5′-UTR polymorphism and genetic susceptibility of colorectal cancer
王琦 1黄俊 1邱强 1黄明文 1周诚亮2
作者信息
- 1. 南昌大学第二附属医院胃肠外科，南昌330006
- 2. 江西省奉新县中医院普外科，奉新330700
- 折叠
摘要
Abstract
Objective To investigate the association between the rs769236 polymorphism at the 5′-UTR region of CyclinA2 gene and the susceptibility of colorectal cancer (CRC) .Methods A case-control study was carried out on the Chinese Han population , the rs769236 polymorphism of CyclinA2 were analyzed by PCR restriction fragment length polymorphism (PCR-RFLP)in 150 CRC cases and 150 healthy controls .The association between CRC risk and the SNP (rs769236) was estimated by an unconditional logis-tic regression model .Results Compared with GG wild genotype ,variant genotypes(GA+AA) carriers had a significantly increased risk of CRC[adjusted odds ratio (OR)=1 .92 ,95% confidence interval(CI)=1 .10 -3 .36] .Conclusion The current results sug-gested that the SNP(rs769236) of CyclinA2 is significantly associated with the increased risk of CRC ,the variant genotypes(GA+AA) are the independent risk factors of CRC in Chinese Han population .关键词
结直肠癌/CyclinA2/单核苷酸多态性Key words
colorectal cancer/CyclinA2/single nucleotide polymorphisms引用本文复制引用
王琦,黄俊,邱强,黄明文,周诚亮..CyclinA2基因5′-UTR多态性与结直肠癌遗传易感性的关系[J].重庆医学,2014,(1):64-66,3.
