重庆医学Issue(1)：77-79,82,4.DOI:10.3969/j.issn.1671-8348.2014.01.027
生长抑素与前列腺素 E1联合应用治疗重症急性胰腺炎初步临床研究
Preliminary clinical study of somatostatin combined with prostaglandin E1 in patients with severe acute pancreatits
瞿星光 1张朝晖 1周刚 1龚勋 1张蓉 1曾超 1李灵丰 1钟建华 1姚玲1
作者信息
- 1. 三峡大学第一临床医学院/宜昌市中心人民医院重症医学科，湖北宜昌443003
- 折叠
摘要
Abstract
Objective To study the effect of somatostatin(SS) combined with prostaglandin E1 (PGE1) in patients with severe acute pancreatits (SAP) and to elucidate its underlying mechanisms .Methods 31 cases of SAP patients were randomly divided into control group (SS group ,n=15) and combined treatment group (group SS+ PGE1 ,n=16) .On the first ,4th ,7th day after admis-sion ,the peripheral blood endotoxin ,TNF-α,IL-6 ,IL-10 and CRP changes of patients in two groups were detected ;PLT ,TT ,PT , APTT ,FIB and D two dimer were monitored ;serum amylase and lactate dehydrogenase (LDH ) and serum albumin (ALB ) were detected ;and ICU occupancy time ,after 14 d treatment APACHE Ⅱ ,Binder integral ,transit operation rate ,the mortality of 28 d were also observed .Results Compared with control group ,the treatment group for the treatment of 7 ,14 days after the clinical and laboratory parameters were improved ,and there were significant difference .Conclusion SS and PGE1 combination can significantly improve the prognosis of patients with SAP ,reduce ICU inpatient time and the mortality of 28 d ,its possible mechanism of action would be to reduce acute phase inflammatory mediators and the release of cytokines ,improve the immunity of the organism ,multi-level ,improve the pancreatic microcirculation ,correct the hypercoagulable state ,and avoid complications of multiple organ dysfunc-tion in SAP patients .关键词
重症急性胰腺炎/生长抑素/前列腺素E1/联合治疗Key words
severe acute pancreatitis/somatostatin/prostaglandin E1/combined therapy引用本文复制引用
瞿星光,张朝晖,周刚,龚勋,张蓉,曾超,李灵丰,钟建华,姚玲..生长抑素与前列腺素 E1联合应用治疗重症急性胰腺炎初步临床研究[J].重庆医学,2014,(1):77-79,82,4.
