重庆医学Issue(2)：200-202,3.DOI:10.3969/j.issn.1671-8348.2014.02.025
超声造影监测丹参治疗兔肾缺血再灌注损伤的实验研究
Experimental study on ultrasound contrast for monitoring Salvia miltiorrhiza in treating rabbit renal ischemia-reperfusion injury
摘要
Abstract
Objective To apply the real-time gray scale contrast-enhanced ultrasonography(CEUS) with quantitative analysis technique to monitor the change of the renal cortex blood perfusion before and after Salvia miltiorrhiza treatment of rabbit renal is-chemia-reperfusion injury and to investigate the application value of the ultrasound contrast for evaluating the effect of medication in the treatment of rabbit renal ischemia-reperfusion injury (IRI) .Methods The rabbit right kidney was resected and the left renal pedicle was occluded for 60 min ischemia ,then the perfusion was recovered for establishing the IRI model .Salvia miltiorrhiza injec-tion was given for observing the pathological changes of the left kidney and the renal cortex blood prefusion under the contrast-en-hanced ultrasonography .The parameters of renal cortex blood perfusion were quantitatively analyzed by the time-intension curves . Results After IRI occurrence ,the time-intensity curve (TIC) of the rabbit renal cortex was slowly ascended .The time to peak (TTP) was extened and the rising slope(Grad) of the curve ascending branch was declined (P< 0 .05);after Salvia miltiorrhiza treatment ,TTP decreased and Grad increased obviously(P<0 .05) .Conclusion CEUS combined with quantitative analysis can re-flect the renal blood perfusion abnormity caused by ischemia-reperfusion and discover the change of the renal blood perfusion after medication treatment .关键词
肾/缺血/再灌注损伤/灰阶超声造影/定量分析/丹参/兔Key words
renal/ischemia/reperfusion injury/gray-scale contrast-enhanced ultrasonography/quantitative analysis/Salvia milti-orrhiza/rabbit引用本文复制引用
叶帆,李明星,罗志建,张敏,宣吉晴,陈晓梅..超声造影监测丹参治疗兔肾缺血再灌注损伤的实验研究[J].重庆医学,2014,(2):200-202,3.基金项目
四川省教育厅科研资助课题（08zc054）。 （）
