重庆医学Issue(3)：257-259,3.DOI:10.3969/j.issn.1671-8348.2014.03.001
骨髓活检组织病理在骨髓增生异常综合征诊断中的价值
Value of bone marrow biopsy histopathological finding in diagnosing myelodysplastic syndrome
摘要
Abstract
Objective To evaluate the value of plastic-embedded bone marrow (BM ) biopsy sections in diagnosing myelodysplas-tic syndrome(MDS) .Methods HGF and Gomori stained .Glycol methacrylate(GMA) embedded BM biopsy specimens were detec-ted from 125 MDS patients with 25 cases in good health as control .Dyshematopoiesis and abnormal stroma cell responses were se-lected as main observed projects .Results Bone marrow biopsy sections gave an exact assessment of cellularity ,19 cases (15 .2% ) showed a decrease of cellularity as hypocellular MDS .66 cases(52 .8% ) of these cases did show abnormal localization of erythro-blastic clusters ,biopsy of 64(62% ) of low risk group 103 cases did show abnormal localization of immature precursors such as blasts and promyelocytes(ALIP positive) .Numeration of megakaryocytes and mast cells within 1mm2 acre of BM tissue were all much in MDS group than in control group .Gomori′s stain revealed moderate increase in reticulin fibres in 65 cases ,10 cases(8 .0% ) showed degree of myelofibrosis were + + + as hyperfibrotic MDS .Among 125 cases ,33 cases(26 .4% ) of bone marrow biopsies showed different types of erythrocytic and granulocytic immature cells with unusual intrasinusoidal bone marrow infiltration .Con-clusion It is clear that GMA embedded BM biopsy section is helpful in making diagnosis of MDS ,and has important clinical appli-cation value .关键词
骨髓增生异常综合征/骨髓活检/组织病理/诊断Key words
myelodysplastic syndrome/bone marrow biopsy/plastic embedding/diagnosis引用本文复制引用
浦杰,陈真,石军,浦权,陆道培..骨髓活检组织病理在骨髓增生异常综合征诊断中的价值[J].重庆医学,2014,(3):257-259,3.基金项目
国家自然科学基金资助项目（81270605）；上海市科学技术委员会平台项目（11140903700）。 （）
