重庆医学Issue(5)：551-552,555,3.DOI:10.3969/j.issn.1671-8348.2014.05.015
磷酸二酯酶4D基因rs153031多态性与不稳定型心绞痛易感性的研究
Relationship of the phosphodiesterase 4D gene rs153031 polymorphism and the susceptibility of unstable angina pectoris
许浩 1何国平 1戚传平 2许联红 2杨海涛 1钱亿超1
作者信息
- 1. 江苏大学附属武进医院 心血管内科，江苏常州213002
- 2. 江苏大学附属武进医院 中心实验室，江苏常州213002
- 折叠
摘要
Abstract
Objective To investigate the association between the phosphodiesterase 4D(PDE4D) gene rs153031 polymorphism and the susceptibility of unstable angina pectoris(UAP) in Chinese Han population of Changwu region .Methods The PDE4D gene rs153031 polymorphism was genotyped by Taqman probe in 172 UAP patients(UAP group) ,as well as in gender-and-age-matched 220 subjects without coronary heart disease(CHD)(control group) .Results In this crowd ,there was PDE4D gene rs153031 poly-morphism in patients with UAP and in subjects without CHD .Compared with control group ,frequencies of GG ,GA ,AA genotypes and G allele of rs153031 in UAP group showed no statistical differences (P> 0 .05) .Conclusion In Chinese Han population of Changwu region ,PDE4D gene rs153031 polymorphism shows no association with the susceptibility of UAP .关键词
心绞痛 ,不稳定型/环核苷酸磷酸二酯酶类 ,4型/基因多态性Key words
angina ,unstable/cyclic nucleotide phosphodiesterases ,type4/gene polymorphism引用本文复制引用
许浩,何国平,戚传平,许联红,杨海涛,钱亿超..磷酸二酯酶4D基因rs153031多态性与不稳定型心绞痛易感性的研究[J].重庆医学,2014,(5):551-552,555,3.
