重庆医学Issue(6)：641-643,647,4.DOI:10.3969/j.issn.1671-8348.2014.06.001
慢性 HBV 感染者不同免疫状态证候虚实分类与T、B及NK细胞亚群的相关性研究
The TCM syndrome classification of different immune status of chronic HBV infection and T,B and NK cells subgroup correlation studies
摘要
Abstract
Objective To investigate the different immune status of TCM classification and the levels of T and B cells and the re-lationship between the NK cells .Methods Three different immune state of patients with chronic HBV were divided into asthenia syndrome(AS) group and sthenia syndrome(SS) group ,and then we detected the peripheral blood lymphocyte subsets and NK cells ,and compared the above each index analysis .Results In three different immune status ,all patients with AS and SS groups CD4+ T cell percentages are lower than normal control group (P<0 .05) ,and in a state of immune tolerance ,CD4+ T cells of SS group were lower than the AS group (P<0 .05) ,in a state of immune clearance ,CD8+ T cell percentage were SS group> control group> the AS group (P<0 .05) .Three different immune status ,the ratio of CD4+ /CD8+ SS group were significantly lower than the AS group or control group ,in a state of immune clearance the SS and the AS group B lymphocyte percentage were higher than the control group ,the percentage of NK cells was lower than the control group (P<0 .05) .Conclusion Chronic HBV infection have immune dysfunction ;HBV infected different immune status of TCM classification have relationship with T and B cell subsets and NK cells ,and the immune function test has certain clinical application value for the judgment of TCM syndrome type .关键词
T淋巴细胞/B淋巴细胞/杀伤细胞,天然/慢性乙型肝炎/免疫状态/中医证型分类Key words
T-lymphocytes/B-lymphocytes/killer cells ,natural/chronic hepatitis B viral hepatitis/immune status/TCM syndrome classification引用本文复制引用
张兵,杨丽莎,唐美媛,张敏,聂琳..慢性 HBV 感染者不同免疫状态证候虚实分类与T、B及NK细胞亚群的相关性研究[J].重庆医学,2014,(6):641-643,647,4.基金项目
国家自然科学基金资助项目（81260602）；广西中医药管理局中医药科技专项课题立项资助项目（GZKZ09-85）。 （）
