重庆医学Issue(6)：689-691,695,4.DOI:10.3969/j.issn.1671-8348.2014.06.019
黄连解毒汤对丙戊酸钠在氯化锂-匹罗卡品致癫痫大鼠体内的减毒增效作用
Synergistic effect of Huang Lian Jie Du Decoction on sodium valproate in epileptic rats induced by lithium chloride-pilocarpine
摘要
Abstract
Objective To investigate synergistic effect of Huang Lian Jie Du decoction (HLT) on sodium valproate(SVA) in epi-leptic rats by epileptic rats induced by lithium chloride-pilocarpine .Methods Epileptic rats were induced by intraperitoneal injection of lithium chloride and pilocarpine .The synergistic anti-epilepsy effect of HLT and SVA was investigated .The level of ALT ,AST , SVA in serum ,GSH-Px and MDA were determined at the end of a 4 week adminstration .Then the ultrastructure alteration of the liver were also observed by transmission electon microscope .Results The adminstration of SVA together with HLT can reduce be-havior of epileptic rats .Significant decrease in the level of ALT ,AST ,and SVA in serum of rats and noticeable increases in the ac-tivity of GSH-Px were observed in the co-administered groups compared with administere SVA alone group(P<0 .01) .At the same time ,light microscopic study indicates rats in co-administered SVA and high-dose HLT group has intacthepatic histology .Conclu-sion HLT could has synergistic anti-epileptic effect and relieve the hepatotoxoicity of SVA when co-administered .关键词
丙戊酸钠/黄连解毒汤/肝毒性Key words
sodium valproate/Huang Lian Jie Du Decoction/hepatotoxicity引用本文复制引用
周海云,李品军,王强,黄明春,刘耀..黄连解毒汤对丙戊酸钠在氯化锂-匹罗卡品致癫痫大鼠体内的减毒增效作用[J].重庆医学,2014,(6):689-691,695,4.基金项目
国家科技部重大新药创制专项（2010ZX09401-306-1-3）。 （）
