重庆医学Issue(7)：785-787,3.DOI:10.3969/j.issn.1671-8348.2014.07.006
PTEN、P27和BAG-1在子宫内膜癌中的表达及临床意义
The expression and clinical significance of PTEN,P27 and BAG-1 in endometrial carcinoma
摘要
Abstract
Objective To stduy the expression of PTEN ,P27 and BAG-1 in endometrial carcinoma ,and to analysis the clinical significance .Methods The expression of PTEN ,P27 and BAG-1 in 102 cases of endometrial carcinoma ,90 cases of endometrial hy-perplasia and 44 cases of normal endometrium tissue were detected by immunohistochemistry .Results PTEN and P27 in endome-trial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .The expression of PTEN and BAG-1 were well correlated to histology degree and muscular infiltration .BAG-1 expression also had a well correlated to clinical stage .In this study ,we had not find a correlated between the expression of P27 and clinical and pathology characteristic of patien . PTEN expression had a Pearson relevance to P27 or BAG-1 expression ,but there was no correlation between P27 and BAG-1 .Con-clusion PTEN and P27 in endometrial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .PTEN ,P27 and BAG-1 might play a role in the development of endometrial cancer .关键词
免疫组织化学/子宫内膜肿瘤/PTEN/P27/BAG-1Key words
immunohistochemistry/endometrial neoplasms/PTEN/P27/BAG-1引用本文复制引用
梁艳芳,曾今诚,康东平,王玲梅,陈灿,阮建波..PTEN、P27和BAG-1在子宫内膜癌中的表达及临床意义[J].重庆医学,2014,(7):785-787,3.基金项目
广东省科技计划项目（2009B03081333）；广东医学院青年基金项目（XQ1124）。 （）
