重庆医学Issue(9)：1069-1071,3.DOI:10.3969/j.issn.1671-8348.2014.09.016
p53在乳腺癌中的表达及其临床意义
The expression of p53 in breast cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of p53 in breast cancer and its clinical significance .Methods The clinical pathological data of 214 cases of breast cancer patients were collected ,and retrospective analyzed of p53 protein expression and its correlation with clinical pathological features .Results The positive rate of p53 was 52 .3% .The expression p53 was no correlation with age ,the size of the lesion(P> 0 .05) ,it was correlation with lymph node metastasis ,histological classification and molecular subtype(r=0 .396 ,0 .309 ,0 .167 ,P=0 .000 ,0 .000 ,0 .014) ,and also have negative correlation with the expression rate of ER ,PR (r= -0 .561 ,-0 .315 ,P=0 .000 ,0 .000) ,positive correlation with HER2 and Ki67(r=0 .374 ,0 .153 ,P=0 .000 ,0 .026) .In the group of triple negative breast cancer (TNBC) and the group of non-TNBC ,the difference was statistically significant of expression of p53 (P<0 .05) .Conclusion p53 protein has closely related with the development ,relapse and metastases of breast cancer ,the detection of p53 can be used to guide the individualized therapy and as a reference index to evaluate the prognosis of breast cancer .关键词
基因,p53/乳腺肿瘤/预后Key words
genes ,p53/breast neoplasms/prognosis引用本文复制引用
陈茂山,袁杰,成宏,杨光伦..p53在乳腺癌中的表达及其临床意义[J].重庆医学,2014,(9):1069-1071,3.基金项目
国家临床重点专科建设资助项目。 （）
