重庆医学Issue(9)：1090-1092,3.DOI:10.3969/j.issn.1671-8348.2014.09.024
介入法建立比格犬和小型猪急性心肌梗死模型的对比研究
The comparison of establishment of the acute myocardial infarction model between the beagle dogs and the mini-pigs by interventional technique
顾晓龙 1黄军 1董正华 1雷辉燕 2龚志华 3文艳飞 3向定成3
作者信息
- 1. 南方医科大学研究生学院，广州510515
- 2. 广州军区总医院超声影像科，广州510010
- 3. 广州军区总医院心血管内科，广州510010
- 折叠
摘要
Abstract
Objective To explore the success rate and the risk of establishment of the acute myocardial infarction model between the beagle dogs and the mini-pigs by interventional technique ,further to provid theoretical basis for choose a more suitable animal model .Methods 6 dogs and 6 mini-pigs were anaesthetized ,then underwent the coronary arteriography via femoral artery .After is-chemic preconditioning the coronary balloon was inflated to occlude the middle left anterior descending coronary for 180 minutes . The electrocardiogram was examined throughout the operation and the pathological sections were examined until the animals were executed one week later .Results All beagle dogs survived ,while 1 case of mini-pigs dead(1/6) .There was 1 cases(1/6) of beagle dogs had acute myocardial infarction ,while 5(5/6)cases in mini-pigs .All mini-pigs had malignant arrhythmia(6/6) but never seen in beagle dogs .The time needed for building a model was similar between the two groups ,the difference had no statistical signifi-cance(P>0 .05) .Conclusion The risk of establish myocardial infarction model in mini-pigs is higher than beagle dogs ,but the suc-cess rate is still high ,it might be the better choice .关键词
心肌梗死/猪 ,雏型/模型 ,动物Key words
myocardial infarction/swine ,minjature/models ,animal引用本文复制引用
顾晓龙,黄军,董正华,雷辉燕,龚志华,文艳飞,向定成..介入法建立比格犬和小型猪急性心肌梗死模型的对比研究[J].重庆医学,2014,(9):1090-1092,3.
