南方医科大学学报Issue(10)：1442-1447,6.
洗心汤对SAD大鼠脑内tau蛋白O-GlcNAc糖基化修饰相关酶的影响
Effects of Xixin decoction on enzymes related to O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease
摘要
Abstract
Objective:To study the effects of Xixin decoction (XXD) on O-GlcNAc transferase (OGT) and O-GlcNAc glycosidase in O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease (SAD) and explore the possible mechanism. Methods Male SD rats were randomly divided into sham-operated group, model group, donepezil group, and low-, moderate-, and high-dose XXD groups. After treatment and behavioral test, the rats were sacrificed for detecting the expressions of OGT and O-GlcNAc glycosidase in the brain using immunohistochemistry and Western blotting. Results XXD significantly enhanced the expressions of OGT in the hippocampus of SAD rats and lowered the expression of O-GlcNAc glycosidase (P<0.05 or 0.01). OGT and O-GlcNAc glycosidase expressions showed no significant differences between the model group and donepezil group (P>0.05). Conclusion XXD can regulate the expression of OGT and O-GlcNAc glycosidase to enhance O-GlcNAc glycosylation of tau proteins in the hippocampus of SAD rats.关键词
散发性老年性痴呆/洗心汤/SAD模型/O-GlcNAc糖基转移酶/O-GlcNAc糖苷酶Key words
sporadic Alzheimer's disease/Xixin decoction/O-GlcNAc transferase/O-GlcNAc glycosidase引用本文复制引用
第五永长,田金洲,时晶..洗心汤对SAD大鼠脑内tau蛋白O-GlcNAc糖基化修饰相关酶的影响[J].南方医科大学学报,2013,(10):1442-1447,6.基金项目
国家自然科学基金（30973738） Supported partially by National Natural Science Foundation of China (30973738) （30973738）
