南方医科大学学报Issue(11)：1624-1627,4.
香芹酚预处理减轻小鼠心肌缺血再灌注时氧化应激及细胞凋亡
Carvacrol pretreatment attenuates myocardial oxidative stress and apoptosis following myocardial ischemia-reperfusion in mice
摘要
Abstract
Objective To investigate the effect of carvacrol pretreatment on myocardial ischemia-reperfusion (I/R) injury and its underlying mechanisms. Methods Wild-type male C57 BL/6 mice were randomized into 5 groups (n=13), namely the sham-operated group, vehicle (DMSO in saline)+I/R group, carvacrol (20 mg/kg)+I/R group, carvacrol (40 mg/kg)+I/R group, and carvacrol (60 mg/kg)+I/R group. The mouse models of myocardial I/R injury were established by a 45-min occlusion of the left anterior descending coronary artery (LAD) followed by reperfusion for 2 h. Carvacrol or vehicle was administered intravenously 15 min before LAD occlusion. After reperfusion, the mice were examined for myocardial oxidative stress level and apoptosis rate. Results Compared with the vehicle group, the 3 carvacrol-pretreated groups showed significantly reduced myocardial infarct size, oxidative stress level and cardiac myocyte apoptosis rate (P<0.01). Conclusion Carvacrol can protect against myocardial I/R injury by inhibiting myocardial oxidative stress and apoptosis in mice.关键词
香芹酚/心脏/缺血再灌注损伤/氧化应激/凋亡Key words
carvacrol/heart/ischemia-reperfusion injury/oxidative stress/apoptosis引用本文复制引用
宋旭东,陈爱华,刘映峰,王先宝,周贻军,刘磊,张秀丽,王丽姿,杨平珍..香芹酚预处理减轻小鼠心肌缺血再灌注时氧化应激及细胞凋亡[J].南方医科大学学报,2013,(11):1624-1627,4.基金项目
国家自然科学基金（81270218）；广州市科技计划项目（2011J4300101)Supported by National Natural Science Foundation of China (81270218) （81270218）
