南方医科大学学报Issue(12)：1811-1814,4.DOI:10.3969/j.issn.1673-4254.2013.12.22
CDK6在鼻咽癌中的表达及临床意义
Expression of CDK6 in nasopharyngeal carcinoma and its clinical significance
摘要
Abstract
Objective To explore the expression of CDK6 in nasopharyngeal carcinoma (NPC) and explore its clinical significance. Methods Immunohistochemistry was used to examine the differential expression of CDK6 protein in 101 NPC and 30 nasopharyngeal tissues, and the correlation of CDK6 expression with the clinical characteristics was analyzed in NPC cases. Results Immunohistochemistry demonstrated that CDK6 protein was a co-expressed factor in the cytoplasm and cell nuclei. CDK6 was expressed predominantly in the cytoplasm in nasopharyngeal tissues, but in NPC tissues, CDK6 was co-expressed predominantly in the cytoplasm and nuclei. Compared to the nasopharyngeal tissues, NPC tissues showed significantly up-regulated CDK6 expression (P=0.009) in positive correlation with tumor size (P=0.020) and clinical stages (P=0.0039). Conclusion Increased CDK6 protein expression is an unfavorable factor that promotes the development and progression of NPC.关键词
鼻咽癌/CDK6/免疫组化Key words
nasopharyngeal carcinoma/CDK6/immunohistochemistry引用本文复制引用
罗小鹏,覃继新,黄永秩,刘津,王莹,王怀飞,陈家军..CDK6在鼻咽癌中的表达及临床意义[J].南方医科大学学报,2013,(12):1811-1814,4.基金项目
广西自然科学基金 （）
