南方医科大学学报Issue(12)：1815-1818,1830,5.DOI:10.3969/j.issn.1673-4254.2013.12.23
晚期结直肠癌联合化疗后卡培他滨维持治疗的临床评价
Efficacy and tolerance of maintenance therapy in patients with incurable advanced colorec-tal cancer
摘要
Abstract
Objective To evaluate efficacy, safety, and feasibility of maintenance therapy with capecitabine after fluoropyrimidines/oxaliplatin or fluoropyrimidines/irinotecan chemotherapy in patients with incurable colorectal cancer. Methods Seventy-three hospitalized patients with incurable colorectal cancer who received fluoropyrimidines/oxaliplatin or fluoropyrimidines/irinotecan as the first-line chemotherapy between May 2009 and December 2012 in our department were retrospectively analyzed. When the maximum percentage tumor size reduction was achieved, 42 patients received a maintenance therapy with capecitabine at 1000 mg/m2 in two daily doses on days 1-14, and the other 31 patients without further chemotherapy or the maintenance therapy were followed up. The treatment was repeated every 3 weeks as a cycle until disease progression or intolerable toxicity. The efficacy and safety were evaluated by Kaplan-Meier analysis and χ2 analysis. Results The 42 patients receiving capecitabine maintenance therapy achieved a median progression free survival (PFS) of 11.6 months (95%CI 7.8-15.4), significantly longer than the PFS of 7.4 months (95% CI 4.9-11.8) in the 31 patients without the maintenance therapy (P<0.01). The response rate (RR) after combined chemotherapy in the two groups were similar (42.8% vs 38.7%). χ2 analysis indicated significant reductions in the adverse reactions (P<0.05) in both groups after therapy without significant differences between the two groups (P>0.05) except for hand-foot syndrome. Conclusion In patients with incurable colorectal cancer, capecitabine maintenance therapy following combined chemotherapy can achieve a prolonged PFS with a good safety and tolerance and retains the possibility of further intense therapy in the event of disease progression.关键词
晚期结直肠癌/卡培他滨/维持治疗/耐受性Key words
advanced colorectal cancer/capecitabine/maintenance therapy/tolerance引用本文复制引用
杨冬阳,黎莹,刘建化,江韦韦,马冬..晚期结直肠癌联合化疗后卡培他滨维持治疗的临床评价[J].南方医科大学学报,2013,(12):1815-1818,1830,5.基金项目
广东省科技计划项目 （）
