南方医科大学学报Issue(12)：1852-1855,4.DOI:10.3969/j.issn.1673-4254.2013.12.32
肺动脉平滑肌细胞增殖的分子信号机制研究进展
Progress in research of molecular mechanisms of pulmonary arterial smooth muscle cell pro-liferation
摘要
Abstract
Pulmonary hypertension (PAH) is a common clinical syndrome characterized by elevated pulmonary arterial pressure. The pathological changes in PAH include increased vasoconstrictor tone, thrombosis in situ and pulmonary vascular remodeling. Pulmonary arterial smooth muscle cell (PASMC) proliferation is a hallmark of pulmonary vascular remodeling, and exploration of the molecular mechanisms of PASMC proliferation and intervention of the involved signaling pathways is therefore of great importance for prevention and treatment of PAH. This review focus primarily on the current understanding of the molecular mechanisms involved in the proliferation of PASMCs.关键词
肺动脉高压/肺血管重塑/平滑肌细胞/分子机制Key words
pulmonary hypertension/pulmonary vascular remodeling/smooth muscle cells/molecular mechanisms引用本文复制引用
吴媛媛,王贵佐,李满祥..肺动脉平滑肌细胞增殖的分子信号机制研究进展[J].南方医科大学学报,2013,(12):1852-1855,4.基金项目
国家自然科学基金(81070045，81170051)Supported by National Natural Science Foundation of China (81070045，81170051) （81070045，81170051）
