南方医科大学学报Issue(1)：117-120,4.
乌司他丁对老年人胃肠道大手术围术期心脏功能的影响
Effect of ulinastatin for perioperative cardiac protection in elderly patients undergoing ma-jor gastrointestinal surgery
摘要
Abstract
Objective To study protective effect of ulinastatin on perioperative cardiac function in elderly patients undergoing major gastrointestinal surgery. Methods Sixty elderly patients (32 male and 28 female patients) aged 60-82 years scheduled for major gastrointestinal surgery were randomized into ulinastatin group and control group. The patients in ulinastatin group received 2 × 105 U ulinastatin rapidly administered via a intravenous pump immediately before operation with subsequent continuous infusion at the rate of 1 × 105 U until the completion of surgery, and those in the control group received the same amount of saline instead. In both groups, the mean arterial pressure (MAP), heart rate (HR), left ventricular ejection fraction (LVEF), and cardiac output (CO) were monitored immediately before surgery (T0) and at 1 h (T1), 2 h (T2) and 3 h (T3) after the start of surgery. The total dopamine dose used was recorded at the end of surgery, and blood samples were collected at T0 and at 6 h (T4) and 12 h (T5) after the operation for determination of serum levels of cTn, CK-MB and BNP. Results In both groups, MAP, LVEF and CO were significantly decreased at T2 and T3 (P<0.05) and serum levels of cTn, CK-MB and BNP significantly increased at T4 and T5 compared to those at T0 (P<0.05). Compared with the control group, the patients in ulinastatin group showed significantly higher MAP, LVEF and CO at T2 and T3 and lower serum levels of cTn, CK-MB and BNP at T4 and T5. Conclusion Ulinastatin offers effective perioerative cardiac protection in elderly patients undergoing major gastrointestinal surgery.关键词
乌司他丁/胃肠道大手术/心脏功能Key words
ulinastatin/gastrointestinal surgery/cardiac function引用本文复制引用
陈力,徐世元,李传翔,宋伏虎,王怡..乌司他丁对老年人胃肠道大手术围术期心脏功能的影响[J].南方医科大学学报,2014,(1):117-120,4.基金项目
广东省自然科学基金 （）
