南方医科大学学报Issue(2)：164-168,5.
miR-520a调控ErbB4的表达并抑制食管鳞癌细胞的增殖与侵袭
miR- 520a regulates ErbB4 expression and suppresses proliferation and invasion of esophageal squamous cell carcinoma
摘要
Abstract
Objective To investigate the role of miR-520a in regulation ErbB4 expression and the biological behavior of esophageal squamous cell carcinoma (ESCC). Methods The role of miR-520a in regulating the expression of ErbB4 was investigated by Western blotting and luciferase reporter assay system. The effect of miR-520a on the proliferation and invasion of ESCC cells was detected by MTT and Transwell invasion assay, respectively. Results Western blotting and luciferase reporter assay revealed that miR-520a down-regulated the expression of ErbB4 in vitro. miR-520a significantly inhibited the proliferation and suppressed the invasion of ESCC cell line Eca109. Conclusion miR-520a regulates the expression of ErbB4 and suppresses the proliferation and invasion of ESCC cells in vitro, suggesting its role as a tumor suppressor.关键词
miR-520a/ErbB4/食管鳞癌/增殖/侵袭Key words
miR-520a/ErbB4/esophageal squamous cell carcinoma/proliferation/invasion引用本文复制引用
叶文广,姚青林,张明鑫,闻勤生,王景杰..miR-520a调控ErbB4的表达并抑制食管鳞癌细胞的增殖与侵袭[J].南方医科大学学报,2014,(2):164-168,5.基金项目
国家自然科学基金（81302055）；唐都医院科技发展基金 （）
