南方医科大学学报Issue(2)：236-240,5.
菝葜活性成份对慢性盆腔炎大鼠子宫组织肿瘤坏死因子-ɑ和白介素-4的影响
Effect of Smilax china bioactive fraction on tumor necrosis factor-α and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease
摘要
Abstract
Objective To study the mechanism that mediates the therapeutic effect of the bioactive fraction of Baqia (Smilax china) on chronic pelvic inflammatory disease (CPID). Methods Seventy rats were randomized into CPID model group, sham-operated group, normal control group, Jingangteng capsule group, and high-, medium-, and low-dose Baqia groups. Rat models of CPID were established by inducing chemical burns of the uterus and corresponding treatments were administered. After 14 days of treatment, the rat uterus was observed for swelling and inhibition rate, and the expressions of tumor necrosis factor-α(TNF-α) and interleukin-4 (IL-4) in the uterine tissues were determined using enzyme-linked immumsorbent assay. Results The bioactive fraction of Baqia at the 3 doses obviously reduced the inflammatory cells in the endometrium, promoted epithelial cell proliferation, and ameliorated congestion and edema of the serosa. High and medium doses of Baqia bioactive fraction significantly decreased uterus swelling rate of the rats (P<0.01). All the 3 doses of the Baqia biaoactive fraction obviously decreased uterine TNF-αcontent (P<0.01) and significantly increased uterine IL-4 expression level (P<0.05), and IL-4 up-regulation was especially obvious in high and medium dose groups (P<0.01). Conclusion Baqia bioactive fraction can ameliorate uterine swelling, lower uterine TNF-α and increase IL-4 expressions in rats with CPID, which may be a pharmacological mechanism underlying its therapeutic effect on CPID and cervical adhesion.关键词
菝葜/慢性盆腔炎/肿瘤坏死因子-α/白细胞介素-4Key words
Smilax china/chronic pelvic inflammatory disease/tumor necrosis factor-α/interleukin-4引用本文复制引用
罗艳琴,马云,宋路瑶,罗红成,侯连兵..菝葜活性成份对慢性盆腔炎大鼠子宫组织肿瘤坏死因子-ɑ和白介素-4的影响[J].南方医科大学学报,2014,(2):236-240,5.基金项目
广东省医院药学研究基金（奥赛康基金） （）
